Video: Kev hloov pauv covalent cuam tshuam li cas rau kev ua enzyme?
2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36
Cov covalent txuas ntawm lwm molecule tuaj yeem hloov kho tus kev ua si ntawm cov enzymes thiab ntau lwm cov proteins. Hauv cov xwm txheej no, tus neeg pub khoom molecule muab qhov ua haujlwm moiety uas hloov kho cov khoom ntawm enzyme . Phosphorylation thiab dephosphorylation yog feem ntau tab sis tsis yog tib txoj kev ntawm covalent hloov kho.
Kuj paub yog, kev hloov kho covalent yog dab tsi?
Covalent hloov kho yog enzyme-catalysed alterations ntawm synthesized proteins thiab muaj xws li ntxiv los yog tshem tawm cov tshuaj pab pawg. Kev hloov kho tuaj yeem tsom ib hom amino acid lossis ntau cov amino acids thiab yuav hloov cov tshuaj lom neeg ntawm qhov chaw.
Tsis tas li ntawd, kev hloov pauv enzyme yog dab tsi? Kev hloov kho enzyme : alteration ntawm enzyme cov qauv thiab yog li ntawd, nws txoj haujlwm thiab nws cov haujlwm catalytic los tsim cov metabolites tshiab kom tso cai rau txoj hauv kev tshiab ntawm cov tshuaj tiv thaiv.
Tom qab ntawd, kev hloov pauv covalent puas rov qab tau?
Tus neeg txais khoom feem ntau yog serine, threonine, lossis tyrosine residue, amino acids uas muaj hydroxide. Cov txheej txheem ntawm covalent hloov kho tej zaum thim rov qab , tab sis tsis yog nyob rau hauv txhua rooj plaub. Ib qho piv txwv ntawm covalent Kev tswj hwm yog protein phosphorylation.
Puas yog acetylation yog kev hloov kho covalent?
N-terminal acetylation yog ib qho ntawm kev sib koom ua ke ntau tshaj plaws covalent kev hloov kho ntawm cov proteins hauv eukaryotes, thiab nws yog qhov tseem ceeb rau kev tswj hwm thiab kev ua haujlwm ntawm cov protein sib txawv. N-terminal acetylation plays lub luag haujlwm tseem ceeb hauv kev sib txuas, kev ruaj ntseg thiab hauv zos ntawm cov proteins.
Pom zoo:
Vim li cas tom qab kev hloov pauv kev hloov pauv tseem ceeb?
Kev hloov pauv tom qab kev txhais lus (PTMs) xws li glycosylation thiab phosphorylation ua lub luag haujlwm tseem ceeb ntawm kev ua haujlwm ntawm hemostatic proteins thiab tseem ceeb heev hauv kev teeb tsa kab mob. Xws li theem nrab hloov pauv rau cov proteins hemostatic muaj ntau yam cuam tshuam rau lawv lub peev xwm los cuam tshuam nrog lwm cov proteins
Dab tsi yog qhov txawv ntawm ib puag ncig kev hloov pauv thiab kev hloov pauv qub txeeg qub teg?
Qhov sib txawv ntawm cov yam ntxwv ntawm cov tib neeg ntawm tib hom yog hu ua variation. Qhov no yog inherited variation. Qee qhov kev hloov pauv yog qhov tshwm sim ntawm qhov sib txawv ntawm ib puag ncig, lossis ib tus neeg ua dab tsi. Qhov no yog hu ua environmental variation
Thaum ib qho kev sib cais ua rau muaj kev hloov pauv hloov pauv ntawm lub ntiaj teb nce ntxiv?
Txij li thaum lub kaw lus raug cais tawm, tsis muaj cua sov tuaj yeem khiav tawm (tus txheej txheem yog li adiabatic), yog li thaum lub zog ntws tawm hauv lub cev, qhov entropy ntawm qhov system nce, piv txwv li Δ Ssys> 0. Yog li ntawd, lub entropy ntawm lub system yuav tsum tau nce rau ib tug spontaneous txheej txheem nyob rau hauv no cais system
Dab tsi yog qhov txawv ntawm kev cuam tshuam kev cuam tshuam thiab kev cuam tshuam cuam tshuam?
Paub qhov txawv ntawm kev cuam tshuam kev tsim kho thiab kev cuam tshuam puas tsuaj. Kev tsim kev cuam tshuam tshwm sim thaum lub crests ntawm ob nthwv dej ntxiv ua ke. Kev cuam tshuam kev puas tsuaj tshwm sim thaum lub crest ntawm ib yoj raug txo los ntawm lub trough ntawm lwm tus
Lub zog cua sov cuam tshuam li cas rau kev sib cuam tshuam tshuaj?
Cov tshuaj tiv thaiv tshuaj feem ntau cuam tshuam nrog kev hloov pauv ntawm lub zog vim kev tawg thiab tsim cov ntawv cog lus. Cov tshuaj tiv thaiv uas lub zog raug tso tawm yog cov tshuaj tiv thaiv exothermic, thaum cov uas siv lub zog cua sov yog endothermic