Cov txheej txheem:

Vim li cas tom qab kev hloov pauv kev hloov pauv tseem ceeb?
Vim li cas tom qab kev hloov pauv kev hloov pauv tseem ceeb?

Video: Vim li cas tom qab kev hloov pauv kev hloov pauv tseem ceeb?

Video: Vim li cas tom qab kev hloov pauv kev hloov pauv tseem ceeb?
Video: Saib Mis paub Poj niam (hluas nkauj) tus yam ntxwv lub siab 2024, Kaum ib hlis
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Tshaj tawm - kev hloov kho kev txhais lus (PTMs) xws li glycosylation thiab phosphorylation ua si tseem ceeb Lub luag haujlwm ntawm kev ua haujlwm ntawm hemostatic proteins thiab tseem ceeb hauv kev teeb tsa tus kab mob. Xws li theem nrab hloov pauv rau cov proteins hemostatic muaj ntau yam cuam tshuam rau lawv lub peev xwm los cuam tshuam nrog lwm cov proteins.

Raws li txoj cai, lub hom phiaj ntawm kev hloov pauv tom qab kev hloov pauv yog dab tsi?

PTMs yog tshuaj kev hloov kho uas ua lub luag haujlwm tseem ceeb hauv kev ua haujlwm proteomic vim tias lawv tswj hwm kev ua haujlwm, thaj chaw, thiab kev cuam tshuam nrog lwm cov cellular molecules xws li cov proteins, nucleic acids, lipids thiab cofactors. Tshaj tawm - kev hloov kho kev txhais lus yog cov txheej txheem tseem ceeb los ua kom muaj kev sib txawv ntawm proteomic.

Tom qab ntawd, lo lus nug yog, dab tsi yog qhov kev hloov pauv hloov pauv ntau tshaj plaws? Protein phosphorylation (Daim duab 2) yog cov feem ntau nquag kawm ncej - kev hloov kho kev txhais lus . Nws tau raug kwv yees tias ib feem peb ntawm cov tsiaj nyeg proteins yuav raug phosphorylated, thiab qhov no kev hloov kho feem ntau ua lub luag haujlwm tseem ceeb hauv kev hloov pauv cov protein ua haujlwm.

Ua raws li qhov kev pom no, peb hom kev hloov pauv kev hloov pauv tom qab yog dab tsi?

Hom kev hloov kho tom qab kev txhais lus

  • Phosphorylation.
  • Acetylation.
  • Hydroxylation.
  • Methylation.

Puas yog Methylation ib qho kev hloov pauv hloov tom qab?

Methylation yog qhov sib ntxiv ntawm pawg methyl mus rau lysine sab saw lub luag haujlwm rau chromatin transcription kev ua haujlwm xeev. Sulfation yog qhov ruaj khov ncej - kev hloov kho kev txhais lus xav tau rau kev ua haujlwm ntawm cov protein. Purification ntawm ncej - kev txhais lus hloov xav tau cov protein.

Pom zoo: