Video: Kev nkag tsis tiav txhais li cas?
2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36
Penetrance hais txog qhov yuav tshwm sim ntawm qhov chaw kho mob yuav tshwm sim thaum ib qho genotype tshwj xeeb yog tam sim no. Ib yam mob yog hais qhia tsis tiav penetrance thaum qee tus neeg uas muaj cov kab mob pathogenic variant qhia txog kev sib raug zoo thaum lwm tus ua tsis yog.
Ntxiv mus, dab tsi ua rau kev nkag mus tsis tiav?
Kev nkag tsis tiav tej zaum yuav yog vim cov nyhuv ntawm hom kev hloov pauv. Qee qhov kev hloov pauv ntawm tus kab mob muab tuaj yeem ua tiav kev nkag mus , qhov twg raws li lwm tus hauv tib lub noob qhia tsis tiav los yog tsawg heev kev nkag mus . Txo kev nkag mus nyob rau hauv qee yam kab mob caj ces kuj tseem nyob ntawm cov keeb kwm ntawm cov noob caj noob ces.
Ib yam li ntawd, qhov txawv ntawm qhov tsis tiav penetrance thiab variable nthuav qhia yog dab tsi? “ Tsis tiav ”los yog 'txo' kev nkag mus txhais tau hais tias cov noob caj noob ces qhia tsuas yog ib feem ntawm cov pejxeem. Yog li ntawd, qhov no allele tau txo nkag mus zoo li hloov pauv kev nthuav qhia . Variable nthuav qhia hais txog ntau yam ntawm cov cim qhia thiab cov tsos mob uas tuaj yeem tshwm sim hauv txawv cov neeg uas muaj tib yam caj ces.
Hais txog qhov no, qhov piv txwv ntawm kev nkag tsis tiav yog dab tsi?
Hauv tsis tiav los yog txo kev nkag mus , qee tus neeg yuav tsis qhia qhov zoo txawm tias lawv nqa cov allele. Ib piv txwv ntawm ib qho autosomal dominant mob uas qhia tsis tiav penetrance yog tsev neeg mob qog noj ntshav vim kev hloov pauv hauv BRCA1 noob. Cov nkag mus ntawm qhov mob yog li 80%.
Dab tsi yog kev nthuav qhia thiab kev nkag mus?
Penetrance hais txog qhov tshwm sim ntawm cov noob caj noob ces los yog qhov zoo uas tau qhia. Qee qhov xwm txheej, txawm tias muaj qhov tseem ceeb ntawm allele, ib qho phenotype yuav tsis tshwm sim. Kev nthuav qhia Ntawm qhov tod tes, hais txog kev hloov pauv hauv phenotypic qhia thaum ib qho allele yog nkag mus.
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