Lub luag haujlwm ntawm Tfiih hauv kev sau ntawv yog dab tsi?
Lub luag haujlwm ntawm Tfiih hauv kev sau ntawv yog dab tsi?

Video: Lub luag haujlwm ntawm Tfiih hauv kev sau ntawv yog dab tsi?

Video: Lub luag haujlwm ntawm Tfiih hauv kev sau ntawv yog dab tsi?
Video: Leng Yang - Yog Vim Dab Tsi (Official Full Song | Nkauj Tawm Tshiab) 2020/05/24 2024, Kaum ib hlis
Anonim

(NER) TSI yog ib tug general kev sau ntawv qhov tseem ceeb uas ua haujlwm los nrhiav RNA Pol II rau cov neeg txhawb nqa ntawm cov noob. Nws muaj nuj nqi raws li ib tug helicase uas unwinds DNA. Nws kuj tseem tshem tawm DNA tom qab qhov mob DNA tau lees paub los ntawm kev kho genome thoob ntiaj teb (GGR) txoj hauv kev lossis kev sau ntawv -coupled repair (TCR) pathway of NER.

Ib yam li ntawd, nws raug nug, yuav ua li cas hloov pauv cov txheej txheem tswj cov noob qhia?

Transcription yam yog proteins uas tswj tus kev sau ntawv ntawm noob - uas yog, lawv luam tawm rau hauv RNA, ntawm txoj kev ua cov protein. Transcription yam pab kom ntseeg tau tias txoj cai noob yog qhia nyob rau hauv txoj cai hlwb ntawm lub cev, nyob rau lub sij hawm.

Ib yam li ntawd, TATA lub thawv puas tau sau? Kev sau ntawv yog cov txheej txheem uas tsim cov RNA molecule los ntawm DNA ib ntus. Cov TAWS box yog lub npe rau nws qhov kev khaws cia DNA ib ntus, uas feem ntau yog TATAAA. Ntau cov noob eukaryotic muaj kev txuag TAWS box nyob 25-35 puag khub ua ntej lub kev sau ntawv pib qhov chaw ntawm ib tug gene.

Hais txog qhov no, Tfiie yog dab tsi?

Nws yog tetramer ntawm ob alpha thiab ob beta chains thiab cuam tshuam nrog TAF6 / TAFII80, ATF7IP, thiab varicella-zoster virus IE63 protein ntau . TFIIE recruits TFIIH mus rau qhov kev pib ua haujlwm thiab txhawb nqa RNA polymerase II C-terminal domain kinase thiab DNA-dependent ATPase cov haujlwm ntawm TFIIH.

Dab tsi yog lub hom phiaj ntawm kev sau cov ntsiab lus?

Transcription yam yog cov proteins koom nrog hauv cov txheej txheem hloov pauv, lossis hloov pauv, DNA rau hauv RNA. Transcription yam suav nrog ntau cov proteins, tsis suav nrog RNA polymerase, uas pib thiab tswj cov kev sau ntawv ntawm cov noob.

Pom zoo: