Lub luag haujlwm ntawm CDK yog dab tsi hauv lub cev ua haujlwm ntawm tes tshwj xeeb hauv lub voj voog ntawm tes?

2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36

Los ntawm phosphorylation, Cdks teeb liab cell tias nws yog npaj kom dhau mus rau theem tom ntej ntawm lub cell voj voog . Raws li lawv lub npe qhia, Cyclin-Dependent Protein Kinases yog nyob ntawm cyclins, lwm chav kawm ntawm kev tswj hwm cov protein. Cyclins khi rau Cdks , activating cov Cdks phosphorylate rau lwm cov molecules.

Hauv qhov no, lub luag haujlwm ntawm CDK yog dab tsi hauv lub voj voog ntawm tes?

CDKs yog ib tsev neeg ntawm multifunctional enzymes uas tuaj yeem hloov kho ntau yam protein substrates koom nrog cell voj voog kev vam meej. Tshwj xeeb, CDKs phosphorylate lawv cov substrates los ntawm kev xa cov phosphate pawg los ntawm ATP mus rau qhov tshwj xeeb ntawm cov amino acids hauv cov substrates.

Ib yam li ntawd, cyclin d1 lub luag haujlwm ua si hauv kev tswj hwm ntawm lub voj voog ntawm tes? Cyclin D1 ua si ib lub hauv paus luag hauj lwm hauv kev cai ntawm proliferation, txuas lub extracellular signaling ib puag ncig rau cell voj voog kev vam meej [1]. Kev qhia theem ntawm cyclin D1 Nws yog qhov ua tau zoo rau qhov kev txiav txim ntawm cov teeb liab proliferative nrog rau kev loj hlob zoo receptors, Ras, thiab lawv cov nyhuv downstream.

Qhov thib ob, lub luag haujlwm ntawm cyclin dependent kinases hauv lub voj voog ntawm tes yog dab tsi?

Cov haujlwm ntawm cyclin nyob protein ntau kinase yog tswj los ntawm cyclin molecules. Cyclins ua si luag hauj lwm ntawm activating thiab chaperoning CDK rau tej substrates. Lawv tas li tsim thiab degraded thaum lub sij hawm cell voj voog.

Kev tswj ntawm lub voj voog ntawm tes yog dab tsi?

Qhov zoo Kev cai ntawm Cell Cycle Ob pawg ntawm cov proteins, hu ua cyclins thiab cyclin-dependent kinases (Cdks), yog lub luag haujlwm rau kev nce qib cell los ntawm ntau qhov chaw kuaj xyuas. Cyclins tswj tus cell voj voog tsuas yog thaum lawv nruj nruj rau Cdks.