Video: Vim li cas Ames kuaj rau mutagens siv los kuaj cov carcinogens MCAT?
2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36
Lo lus nug nug tus neeg soj ntsuam kom piav qhia vim li cas tus Ames kuaj rau mutagens tuaj yeem yog siv los kuaj cov carcinogens . Hauv Ames xeem , cov tshuaj uas ua rau muaj kev hloov hauv Salmonella xeem hom kab mob muaj peev xwm carcinogens , vim qhov tseeb tias lawv hloov DNA thiab DNA hloov pauv tuaj yeem ua rau mob qog noj ntshav (B).
Tsis tas li ntawd, qhov kev ntsuam xyuas Ames pab tau li cas los txiav txim seb cov tshuaj puas yog mutagenic?
Cov Ames xeem yog ib txoj kev siv dav uas siv cov kab mob test seb a muab tshuaj tuaj yeem ua rau kev hloov pauv hauv DNA ntawm cov xeem kab mob. Ib tug zoo xeem qhia uas tus chemical yog mutagenic thiab yog li ntawd tej zaum yuav ua raws li ib tug carcinogen, vim hais tias mob cancer feem ntau txuas mus rau kev hloov.
Tsis tas li ntawd, lub hom phiaj ntawm lub siab enzymes hauv kev kuaj Ames yog dab tsi? Cov Ames Test combines ib tug kab mob revertant mutation soj ntsuam nrog rau kev simulation ntawm mammalian metabolism los tsim ib tug heev rhiab heev xeem rau cov tshuaj mutagenic hauv ib puag ncig. Ib nas daim siab homogenate yog npaj los tsim ib qho metabolically active extract (S9).
Tsis tas li ntawd, Ames qhov kev sim rau mutagenicity zoo li cas rau kev txheeb xyuas cov kab mob carcinogens?
Cov Ames xeem yog ib txoj hauv kev uas siv cov kab mob mus rau xeem seb ib qho tshuaj twg tuaj yeem ua rau muaj kev hloov pauv hauv DNA ntawm cov xeem kab mob. Ib qho txiaj ntsig zoo los ntawm xeem yuav qhia tau tias cov tshuaj mutagenic thiab yog li ntawd yuav ua raws li ib tug carcinogen , raws li mob qog noj ntshav feem ntau txuas nrog kev hloov pauv.
Qhov kev xeem Ames yog dab tsi thiab nws ua haujlwm li cas?
Cov Ames xeem siv ntau hom kab mob sib txawv ntawm cov kab mob Salmonella los qhia pom muaj kev hloov pauv. Thaum ntxiv cov mutagens thiab daim siab enzymes, kev hloov pauv rov qab yuav tshwm sim thiab lawv yuav loj hlob tuaj.
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