Video: Dab tsi ua rau penetrance?
2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36
Penetrance hais txog kev faib ua feem ntawm cov neeg uas muaj ib qho kev hloov caj ces (xws li kev hloov pauv hauv ib lub noob caj noob ces) uas pom cov cim thiab cov tsos mob ntawm cov kab mob caj ces. Yog tias qee tus neeg muaj kev hloov pauv tsis tau tsim cov yam ntxwv ntawm qhov tsis sib xws, qhov xwm txheej tau hais tias tau txo qis (lossis tsis tiav) nkag mus.
Yog li ntawd, dab tsi ua rau kev nkag mus tsis tiav?
Kev nkag tsis tiav tej zaum yuav yog vim cov nyhuv ntawm hom kev hloov pauv. Qee qhov kev hloov pauv ntawm tus kab mob muab tuaj yeem ua tiav nkag mus , qhov twg raws li lwm tus hauv tib lub noob qhia tsis tiav los yog tsawg heev nkag mus . Txo kev nkag mus nyob rau hauv qee yam kab mob caj ces kuj tseem nyob ntawm cov keeb kwm ntawm cov noob caj noob ces.
dab tsi yog penetrance thiab nthuav qhia? “Ua tiav” nkag mus txhais tau hais tias cov noob los yog cov noob rau ib qho kev zoo yog qhia nyob rau hauv tag nrho cov pejxeem uas muaj cov noob. Kev nthuav qhia Ntawm qhov tod tes, hais txog kev hloov pauv hauv phenotypic qhia thaum ib qho allele yog nkag mus . Rov qab mus rau qhov piv txwv polydactyly, tus lej ntxiv yuav tshwm sim ntawm ib lossis ntau qhov ntxiv.
Yog li ntawd, dab tsi yog penetrance txhais tau tias nyob rau hauv noob caj noob ces?
Penetrance hauv noob caj noob ces yog qhov kev faib ua feem ntawm cov tib neeg nqa ib qho txawv (los yog allele) ntawm ib tug noob (genotype) uas kuj qhia txog ib qho kev sib raug zoo (phenotype). Cov piv txwv zoo siv los qhia cov qib ntawm penetrance yog feem ntau heev nkag mus.
Yuav ua li cas koj xam penetrance hauv noob caj noob ces?
Crude nkag mus Kev kwv yees tuaj yeem muab tau los ntawm kev faib cov naj npawb ntawm cov kab mob ( nkag mus ) cov tib neeg los ntawm tus lej ntawm cov neeg nqa khoom ua haujlwm ( nkag mus raws li txoj cai uas tsis yog- nkag mus , uas yog, cov tib neeg ib txwm muaj ntau tus xeeb leej xeeb ntxwv lossis cov tib neeg uas muaj kev cuam tshuam rau niam txiv thiab menyuam).
Pom zoo:
Dab tsi ntawm pipette yog volumetric thiab nws siv rau dab tsi?
Lub volumetric pipette, noob pipette, lossis lub plab pipette tso cai rau kev ntsuas qhov tseeb (rau plaub qhov tseem ceeb) ntawm qhov ntim ntawm cov tshuaj. Volumetric pipettes feem ntau yog siv rau hauv analytical chemistry los ua cov kev daws teeb meem los ntawm lub hauv paus Tshuag thiab npaj cov kev daws teeb meem rau titration
S sawv rau dab tsi thiab dab tsi tshwm sim hauv theem no?
S theem sawv rau 'Synthesis'. Qhov no yog theem thaum DNA replication tshwm sim. The G2 stage stands for 'GAP 2'
Dab tsi yog cov reagents xav tau rau PCR thiab dab tsi yog qhov ua haujlwm ntawm txhua tus?
Muaj tsib yam tshuaj reagents, lossis cov khoom xyaw, siv hauv PCR: qauv DNA, PCR primers, nucleotides, PCR tsis thiab Taq polymerase. Primers feem ntau yog siv nyob rau hauv khub, thiab DNA ntawm ob lub primers yog amplified thaum lub sij hawm PCR cov tshuaj tiv thaiv
Yuav ua li cas koj xam penetrance hauv noob caj noob ces?
Nco ntsoov tias kev nkag mus yog qhov tshwm sim ntawm cov kab mob uas tau muab rau ib qho genotype. Txhua nqe lus no muaj lub ntsiab lus tshwj xeeb: P(D|A) = penetrance. P(D) = lub hauv paus kev pheej hmoo (kev pheej hmoo ntawm tus kab mob nyob rau hauv cov pej xeem) P(A|D) = allele zaus nyob rau hauv mob. P(A) = allele zaus hauv cov pej xeem tswj
Dab tsi yog qhov tseem ceeb tshaj plaws uas yuav tsum muaj rau cov kua dej ntws hauv cov kav dej Dab tsi lwm yam cuam tshuam rau cov dej ntws?
Thaum ib qho kev quab yuam sab nraud yog exerted rau ntawm cov kua uas muaj, qhov tshwm sim siab yog kis sib npaug thoob plaws hauv cov kua. Yog li txhawm rau kom dej ntws, dej xav tau qhov sib txawv siab. Cov kav dej kuj tuaj yeem cuam tshuam los ntawm cov kua dej, cov yeeb nkab loj, qhov kub thiab txias (cov kav dej khov), cov kua dej ntom ntom