Video: Lub luag haujlwm ntawm Thermogenin yog dab tsi?
2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36
Lub uncoupling protein (UCP) los yog thermogenin yog 33 kDa Sab hauv-membrane mitochondrial protein tshwj xeeb rau xim av adipocytes hauv Cov tsiaj nyeg uas ua haujlwm raws li kev thauj mus los proton, tso cai rau cov cua sov ntawm cov proton gradient tsim los ntawm cov kab ua pa thiab yog li uncoupling oxidative phosphorylation.
Ntxiv mus, Thermogenin nyob qhov twg thiab nws lub hom phiaj yog dab tsi?
Thermogenin ua haujlwm tom qab khi rau purine nucleotides, uas GDP yog tus zoo tshaj plaws thiab ADP thiab ATP tsis tshua muaj txiaj ntsig. Cov protein no recouples phosphorylation nrog tus zog tso tawm rau hauv tus txoj hlab pa. Nws yog nyob ntawm tus nkag rau tus H+ channel rau tus C sab tus sab hauv daim nyias nyias.
Qhov thib ob, Thermogenin ucp1 ua kom sov li cas? UCP1 - kho kom haum xeeb kub tiam nyob rau hauv cov roj xim av uncouples cov kab mob ua pa, tso cai rau ceev substrate oxidation nrog tus nqi qis ntawm ATP ntau lawm. Lub lipase hloov triacylglycerols rau hauv cov rog dawb, uas ua kom muaj zog UCP1 , overriding lub inhibition tshwm sim los ntawm purine nucleotides (GDP thiab ADP).
Tom qab, lo lus nug yog, vim li cas Thermogenin yog ib qho tseem ceeb protein?
Thaum no protein ntau , thermogenin , yog nquag, mitochondria tsim cov cua sov ntau dua li ATP. Tus founder ntawm tsev neeg, thermogenin , tau renamed uncoupling protein ntau 1 lossis UCP1 thiab paub tias yog tseem ceeb hauv kev pab tsiaj kom sov thaum hibernation thiab rau cov menyuam mos kom tswj tau lawv lub cev kub.
Ib qho protein tsis sib txuas ua li cas?
Ib uncoupling protein (UCP) yog mitochondrial inner membrane protein ntau uas yog tswj hwm proton channel lossis transporter. Ib uncoupling protein yog li muaj peev xwm ntawm dissipating proton gradient generated los ntawm NADH-powered pumping protons los ntawm mitochondrial matrix mus rau mitochondrial interemembrane qhov chaw.
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