RTK ua haujlwm li cas?
RTK ua haujlwm li cas?

Video: RTK ua haujlwm li cas?

Video: RTK ua haujlwm li cas?
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RTKs yog transmembrane protein receptors uas pab cov hlwb cuam tshuam nrog lawv cov neeg zej zog hauv cov ntaub so ntswg. Hauv particular, kev khi ntawm ib qho kev taw qhia molecule nrog ib qho RTK qhib tyrosine kinase nyob rau hauv cytoplasmic tus Tsov tus tw ntawm receptor.

Ntawm no, tyrosine kinase ua haujlwm li cas?

Tyrosine kinases yog cov enzymes uas xaiv phosphorylates tyrosine residue nyob rau hauv txawv substrates. Receptor tyrosine kinases yog qhib los ntawm ligand khi rau lawv cov extracellular domain. Ligands yog cov teeb liab ntawm cov xov tooj ntawm tes (xws li EGF, PDGF thiab lwm yam) uas ua rau receptor dimerization (tshwj tsis yog Insulin receptor).

Tsis tas li ntawd, tyrosine kinase receptors ua dab tsi hauv lub cell thaum qhib? Cov protein tsis muaj zog hauv tus cell khi rau phosphorylated tyrosine residues, cov phosphate yog pauv mus rau cov proteins, thiab cov proteins ua active. Tsis yog, qee qhov yog cov protein nyob hauv hauv cytoplasm los yog nucleus cell.

Ua kom pom qhov no, RTK signaling yog dab tsi?

Receptor tyrosine kinases (RTKs) yog cov kev sib raug zoo ntawm cov cell nto receptors rau ntau yam kev loj hlob ntawm polypeptide, cytokines, thiab cov tshuaj hormones. Kev hloov pauv hauv receptor tyrosine kinases ua rau kev ua kom muaj ntau yam teeb liab cascades uas muaj ntau yam cuam tshuam rau kev nthuav qhia protein.

tyrosine kinase receptors nyob qhov twg?

Teeb liab mechanisms downstream ntawm activated tyrosine kinase receptors . Feem ntau, cov chaw nrhiav neeg ua haujlwm phosphotyrosine hauv RTKs yog nyob nyob rau hauv lub C-terminal tus Tsov tus tw tus neeg txais kev pab , lub cheeb tsam juxtambrane, los yog kinase ntxig cheeb tsam.

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