Video: MRNA Splicing ua haujlwm li cas?
2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36
RNA splicing . RNA splicing hauv molecular biology, yog ib daim ntawv ntawm RNA ua nyob rau hauv uas ib tug tshiab ua precursor messenger RNA (pre- mRNA ) cov ntaub ntawv yog hloov mus ua tus neeg xa xov liaison RNA ( mRNA ). Thaum splicing , introns (Non-coding regions) yog tshem tawm thiab exons (Coding Regions) yog koom ua ke.
Hais txog qhov no, dab tsi tshwm sim hauv mRNA Splicing?
RNA splicing . Qhov thib peb loj RNA kev tshwm sim uas tshwm sim hauv koj lub hlwb yog RNA splicing . Thaum splicing , cov introns raug tshem tawm los ntawm pre- mRNA , thiab cov exons yog daig ua ke los tsim ib tug paub tab mRNA uas tsis muaj cov intron sequences.
Qhov thib ob, gene splicing ua haujlwm li cas? Gene splicing yog ib qho kev hloov pauv hloov tom qab uas ib leeg noob muaj peev xwm code rau ntau yam proteins. Gene Splicing yog ua tiav hauv eukaryotes, ua ntej mRNA kev txhais lus, los ntawm kev sib txawv los yog kev cais ntawm thaj tsam ntawm pre-mRNA. Gene splicing yog pom nyob rau hauv siab feem ntawm noob.
Yog li ntawd, RNA splicing yog dab tsi thiab vim li cas nws tseem ceeb?
Qhov tseem ceeb ntawm RNA sib txuas tsis to taub tag nrho, tab sis tus txheej txheem sawv cev ib tseem ceeb taw tes ntawm cov noob tswj, txij li feem ntau cov ntaub ntawv sau tseg tsis tuaj yeem tawm hauv lub nucleus los txhais kom txog thaum lawv cov introns raug tshem tawm. Qhov cuam tshuam ntawm splicing kuj yog tseem ceeb rau manipulation ntawm cov ntaub ntawv genetic.
Yuav ua li cas introns tshem tawm ntawm mRNA?
Introns yog tshem tawm los ntawm RNA ua nyob rau hauv uas lub intro yog looped thiab txiav tawm ntawm exons los ntawm snRNPs, thiab cov exons yog spliced ua ke los tsim cov translatable mRNA . Qhov tshwm sim mature mRNA Tej zaum yuav tawm ntawm lub nucleus thiab muab txhais rau hauv cytoplasm.
Pom zoo:
Lub luag haujlwm ntawm CDK yog dab tsi hauv lub cev ua haujlwm ntawm tes tshwj xeeb hauv lub voj voog ntawm tes?
Los ntawm phosphorylation, Cdks teeb liab lub xov tooj ntawm tes uas nws tau npaj kom dhau mus rau theem tom ntej ntawm lub voj voog ntawm tes. Raws li lawv lub npe qhia, Cyclin-Dependent Protein Kinases yog nyob ntawm cyclins, lwm chav kawm ntawm kev tswj hwm cov protein. Cyclins khi rau Cdks, ua kom cov Cdks rau phosphorylate lwm cov molecules
Cov haujlwm ua haujlwm li cas hauv lej?
Hauv kev ua lej, kev ua haujlwm yog qhov kev sib raug zoo ntawm cov teeb tsa uas koom nrog txhua lub ntsiab lus ntawm thawj zaug raws nraim ib qho ntawm cov txheej thib ob. Cov piv txwv zoo yog cov haujlwm los ntawm cov lej mus rau cov lej lossis los ntawm cov lej tiag mus rau cov lej tiag. Piv txwv li, txoj haujlwm ntawm lub ntiaj teb yog lub luag haujlwm ntawm lub sijhawm
Dab tsi yog lub luag haujlwm thiab cov haujlwm niaj hnub ntawm tus kws tshuaj ntsuam xyuas DNA?
Cov kws tshuaj ntsuam DNA feem ntau ua haujlwm hauv cov chaw soj ntsuam kev ua phem txhaum cai uas lawv tshuaj xyuas cov qauv ntawm DNA txhawm rau txheeb xyuas cov neeg raug liam. Tom qab ua qhov kev ntsuam xyuas ntawm txhua tus qauv, cov kws tshuaj ntsuam xyuas piv cov qauv ntawm tus qauv nrog rau lwm cov qauv paub. Yog tias lawv pom qhov sib tw, lawv tuaj yeem muab cov tub ceev xwm saib xyuas qhov zoo
Yuav ua li cas thaum splicing?
RNA splicing yog tshem tawm ntawm introns thiab koom nrog exons hauv eukaryotic mRNA. Nws kuj tshwm sim hauv tRNA thiab rRNA. Lawv nrhiav qhov kawg ntawm cov introns, txiav lawv deb ntawm exons, thiab koom nrog qhov kawg ntawm cov exons uas nyob ib sab ua ke. Thaum tag nrho cov noob tsis muaj nws cov introns, cov txheej txheem ntawm RNA splicing tiav
Cov txheej txheem dab tsi yog lub luag haujlwm rau txoj haujlwm ua haujlwm sib txawv?
Position-effect variegation (PEV) tshwm sim thaum cov noob ib txwm nyob hauv euchromatin yog sib xyaw nrog heterochromatin los ntawm kev hloov kho lossis hloov pauv. Thaum lub ntim ntim heterochromatin kis thoob plaws heterochromatin / euchromatin ciam teb, nws ua rau kev hloov pauv ntawm kev ntsiag to hauv tus qauv stochastic