Video: Enzyme Inhibition ua haujlwm li cas?
2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36
Ib enzyme inhibitor yog ib qho molecule uas khi rau ib qho enzyme thiab txo nws txoj haujlwm. Kev khi ntawm ib inhibitor tuaj yeem nres lub substrate los ntawm nkag mus rau hauv cov enzymes active site thiab/los yog hinder enzyme los ntawm catalyzing nws cov tshuaj tiv thaiv. Inhibitor kev khi yog yog reversible los yog irreversible.
Kuj nug, ua li cas inhibition cuam tshuam rau kev ua enzyme?
Cov teebmeem ntawm Inhibitors ntawm Kev ua enzyme . Enzyme inhibitors yog cov khoom uas hloov cov catalytic kev ua ntawm enzyme thiab yog li ntawd qeeb, lossis qee zaum, nres catalysis. Kev sib tw inhibition tshwm sim thaum lub substrate thiab ib yam khoom zoo li lub substrate yog ob qho tib si ntxiv rau enzyme.
Tsis tas li ntawd, 3 hom enzyme inhibitors yog dab tsi? Muaj peb hom ntawm reversible inhibitors Kev sib tw, tsis sib tw / sib xyaw, thiab tsis sib tw inhibitors . Kev sib tw inhibitors , raws li lub npe qhia, sib tw nrog substrates los khi rau lub enzyme tib lub sijhawm. Cov inhibitor muaj affinity rau lub active site ntawm ib enzyme qhov twg lub substrate kuj khi rau.
Tsuas yog li ntawd, dab tsi yog qhov enzyme inhibitor thiab nws ua haujlwm li cas?
Enzyme inhibitors yog cov tebchaw uas hloov cov khoom catalytic ntawm cov enzyme thiab, yog li ntawd, qeeb tus nqi tshuaj tiv thaiv, lossis qee zaum, txawm tias nres qhov catalysis. Xws li inhibitors ua haujlwm los ntawm kev thaiv lossis distorting qhov chaw nquag.
Dab tsi yog reversible inhibition ntawm enzyme?
A reversible inhibitor yog ib qho uas, ib zaug tshem tawm, tso cai rau tus enzyme nws yog inhibiting pib ua hauj lwm dua. Nws tsis muaj qhov cuam tshuam tas mus li ntawm enzyme - nws tsis hloov cov duab ntawm qhov chaw nquag, piv txwv li. Reversible Inhibition Tej zaum yuav muaj kev sib tw, tsis sib tw lossis tsis sib tw.
Pom zoo:
Yuav ua li cas yog tias tus kab mob HIV muaj qhov tsis ua haujlwm rov qab transcriptase enzyme?
Cov enzymes tau encoded thiab siv los ntawm cov kab mob uas siv cov ntaub ntawv rov qab ua ib kauj ruam hauv cov txheej txheem ntawm kev rov ua dua. HIV kis rau tib neeg nrog kev siv cov enzyme no. Yog tsis muaj rov qab transcriptase, tus kab mob genome yuav tsis tuaj yeem koom ua ke rau hauv lub xov tooj ntawm tes, ua rau tsis ua haujlwm rov ua dua
Yuav ua li cas yog vim li cas tus qauv ntawm ib qho enzyme tseem ceeb heev rau nws txoj haujlwm hauv cov khoom muaj sia?
Enzymes ua kom cov tshuaj tiv thaiv uas tshwm sim hauv cov hlwb. Qhov kev ua haujlwm no cuam tshuam ncaj qha rau lawv cov qauv, nrog rau txhua qhov enzyme tau tshwj xeeb zoo li tus ua kom muaj zog rau ib qho tshuaj tiv thaiv. Kev poob ntawm cov qauv ua rau poob haujlwm. - Kub, pH, thiab kev tswj cov molecules tuaj yeem cuam tshuam rau kev ua haujlwm ntawm cov enzymes
Dab tsi yog reversible enzyme inhibition?
Ib tug reversible inhibitor yog ib qho uas, ib zaug muab tshem tawm, tso cai rau lub enzyme nws twb inhibiting pib ua hauj lwm dua. Nws tsis muaj qhov cuam tshuam tas mus li ntawm cov enzyme - nws tsis hloov cov duab ntawm qhov chaw nquag, piv txwv li. Reversible Inhibition tej zaum yuav muaj kev sib tw, tsis muaj kev sib tw lossis tsis sib tw
Koj ntsuas tus nqi ntawm enzyme ua haujlwm li cas?
Enzyme assay Enzyme assay yog txoj hauv kev kuaj rau kev ntsuas kev ua haujlwm enzymatic. Qhov kom muaj nuj nqis lossis concentration ntawm ib qho enzyme tuaj yeem qhia tau nyob rau hauv cov nyiaj molar, xws li nrog rau lwm yam tshuaj, lossis hais txog kev ua haujlwm hauv enzyme units. Kev ua enzyme = moles ntawm substrate hloov dua siab tshiab rau ib chav tsev lub sij hawm = tus nqi × cov tshuaj tiv thaiv ntim
Cov txheej txheem dab tsi yog lub luag haujlwm rau txoj haujlwm ua haujlwm sib txawv?
Position-effect variegation (PEV) tshwm sim thaum cov noob ib txwm nyob hauv euchromatin yog sib xyaw nrog heterochromatin los ntawm kev hloov kho lossis hloov pauv. Thaum lub ntim ntim heterochromatin kis thoob plaws heterochromatin / euchromatin ciam teb, nws ua rau kev hloov pauv ntawm kev ntsiag to hauv tus qauv stochastic