Video: Dab tsi yog reversible enzyme inhibition?
2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36
A reversible inhibitor yog ib qho uas, ib zaug tshem tawm, tso cai rau tus enzyme nws yog inhibiting pib ua hauj lwm dua. Nws tsis muaj qhov cuam tshuam tas mus li ntawm enzyme - nws tsis hloov cov duab ntawm qhov chaw nquag, piv txwv li. Reversible Inhibition Tej zaum yuav muaj kev sib tw, tsis sib tw lossis tsis sib tw.
Tib neeg kuj nug, vim li cas enzyme inhibition reversible?
Kev khi ntawm ib inhibitor tuaj yeem nres lub substrate los ntawm kev nkag mus cov enzymes active site thiab/los yog hinder enzyme los ntawm catalyzing nws cov tshuaj tiv thaiv. Inhibitor khi los yog thim rov qab los yog irreversible. Cov no inhibitors hloov cov amino acid tseem ceeb uas yuav tsum tau muaj rau enzymatic kev ua si.
Qhov thib ob, hom enzyme inhibition twg tuaj yeem thim rov qab? inactivates ib enzyme los ntawm noncovalent, yooj yim dua thim rov qab , kev sib tham. Tsis zoo li irreversible inhibitor , ib reversible inhibitor tuaj yeem dissociate los ntawm enzyme . Rov qab inhibitors suav nrog kev sib tw inhibitors thiab tsis sib tw inhibitors.
Qhov thib ob, qhov sib txawv ntawm kev thim rov qab thiab qhov tsis tuaj yeem thim rov qab yog dab tsi?
Enzyme inhibition tuaj yeem yog thim rov qab los yog rov qab tsis tau . Nyob rau hauv summarizing lub Qhov sib txawv ntawm kev thim rov qab thiab irreversible inhibition ; hauv thim rov qab inhibition , cov inhibitor khi nrog cov enzyme uas tsis yog-covalently. Ntawm qhov tod tes, hauv irreversible inhibition , cov inhibitor khi nrog cov enzyme covalently.
Dab tsi yog 3 hom enzyme inhibitors?
Muaj peb hom ntawm reversible inhibitors Kev sib tw, tsis sib tw / sib xyaw, thiab tsis sib tw inhibitors . Kev sib tw inhibitors , raws li lub npe qhia, sib tw nrog substrates los khi rau lub enzyme tib lub sijhawm. Cov inhibitor muaj affinity rau lub active site ntawm ib enzyme qhov twg lub substrate kuj khi rau.
Pom zoo:
Kev sib raug zoo ntawm enzyme concentration thiab cov tshuaj tiv thaiv tus nqi yog dab tsi?
Los ntawm kev ua kom cov enzyme concentration, qhov siab tshaj plaws cov tshuaj tiv thaiv tau nce zoo heev. Cov ntsiab lus: Tus nqi ntawm cov tshuaj tiv thaiv kab mob nce ntxiv thaum lub substrate concentration nce. Enzymes tuaj yeem ua kom nrawm nrawm ntawm cov tshuaj tiv thaiv. Txawm li cas los xij, cov enzymes ua saturated thaum lub substrate concentration siab
Dab tsi yog saturation kinetics ntawm ib qho enzyme?
Txawm li cas los xij, tsis zoo li cov tshuaj tiv thaiv tsis muaj tshuaj lom neeg, cov tshuaj tiv thaiv enzyme-catalysed tso saib saturation kinetics. Ob qho tseem ceeb tshaj plaws kinetic zog ntawm ib qho enzyme yog yooj yim npaum li cas cov enzyme ua saturated nrog ib qho substrate, thiab qhov siab tshaj plaws nws tuaj yeem ua tiav
Enzyme Inhibition ua haujlwm li cas?
Ib qho enzyme inhibitor yog molecule uas khi rau ib qho enzyme thiab txo nws txoj haujlwm. Kev khi ntawm tus inhibitor tuaj yeem nres lub substrate los ntawm kev nkag mus rau lub enzyme lub chaw ua haujlwm thiab / lossis cuam tshuam cov enzyme los ntawm kev ua rau nws cov tshuaj tiv thaiv. Inhibitor binding yog thim rov qab los yog irreversible
Dab tsi yog lwm lo lus rau ib qho enzyme?
Lub npe enzyme feem ntau muab los ntawm nws cov substrate los yog cov tshuaj tiv thaiv nws catalyzes, nrog rau lo lus xaus hauv -ase. Piv txwv li lactase, cawv dehydrogenase thiab DNA polymerase. Cov enzymes sib txawv uas catalyze tib cov tshuaj tiv thaiv yog hu ua isozymes
Dab tsi ntawm enzyme yog catalase?
Chr. Catalase yog ib qho enzyme uas muaj nyob hauv yuav luag txhua yam kab mob uas muaj sia nyob tau raug oxygen (xws li kab mob, nroj tsuag, thiab tsiaj txhu). Nws catalyzes decomposition ntawm hydrogen peroxide rau dej thiab oxygen. Nws yog ib qho tseem ceeb heev enzyme tiv thaiv lub cell ntawm oxidative puas los ntawm reactive oxygen hom (ROS)