Video: Dab tsi yog qhov kev xav tau Garrod ua rau Alkaptonuria?
2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36
Xyoo 1902, Archibald Garrod piav qhia txog kev mob caj ces alkaptonuria raws li "inborn yuam kev ntawm metabolism." Nws tau hais tias kev hloov pauv noob ua rau muaj qhov tsis xws luag hauv txoj hauv kev biochemical kom tshem tawm cov kua dej pov tseg. Lub phenotype ntawm tus kab mob †"cov zis tsaus nti â€" yog ib qho kev xav ntawm qhov yuam kev no.
Ib sab ntawm no, Archibald Garrod nrhiav tau dab tsi?
Archibald Garrod . Yawg Archibald Edward Garrod KCMG FRS (25 Kaum Ib Hlis 1857 - 28 Lub Peb Hlis 1936) yog ib tus kws kho mob Askiv uas tau pib ua haujlwm ntawm kev yug menyuam hauv cov metabolism. Nws kuj nrhiav pom alkaptonuria, nkag siab txog nws qhov qub txeeg qub teg.
Kuj Paub, dab tsi ua rau Garrod xav tias muaj kev yug me nyuam ntawm cov metabolism hauv? Xyoo 1902, Garrod luam tawm ib phau ntawv hu ua Qhov tshwm sim ntawm Alkaptonuria: Kev Tshawb Fawb Hauv Tshuaj Kho Mob. Garrod yog kuj yog thawj zaug los tawm tswv yim hais tias kab mob tau inborn yuam kev ntawm metabolism ” Nws ntseeg tias kab mob tau qhov tshwm sim ntawm qhov ploj lawm lossis tsis tseeb cov kauj ruam hauv lub cev cov tshuaj lom neeg txoj hauv kev.
Kuj tseem yuav paub yog, vim li cas thiaj li muaj ib lub noob ib qho polypeptide hypothesis yuav tsum tau hloov kho?
Nws yog Ameslikas teev raws li tus ib gene - ib qho enzyme hypothesis los ntawm US geneticist George Beadle nyob rau hauv 1945 tab sis tom qab ntawd hloov kho thaum pom tau tias noob kuj encoded nonenzyme proteins thiab tus kheej polypeptide chains. Nws yog tam sim no paub tias ib txhia noob code rau ntau hom RNA koom nrog hauv protein synthesis.
Dab tsi yog Beadle thiab Tatum lub tswv yim?
Beadle thiab Tatum lees paub Garrod's kev xav siv cov kev tshawb fawb genetic thiab biochemical ntawm lub khob cij pwm Neurospora. Beadle thiab Tatum pom cov khob cij pwm mutants uas tsis tuaj yeem ua cov amino acids tshwj xeeb. Hauv txhua tus, kev hloov pauv tau "tawg" ib qho enzyme xav tau los tsim ib qho amino acid.
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