Dab tsi yog kev qhia mutagenesis?
Dab tsi yog kev qhia mutagenesis?

Video: Dab tsi yog kev qhia mutagenesis?

Video: Dab tsi yog kev qhia mutagenesis?
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Qhia mutagenesis , kuj hu ua qhia kev hloov pauv , yog ib qho kev xav hais tias cov kab mob tuaj yeem teb rau ib puag ncig kev ntxhov siab los ntawm orthogenetically qhia Kev hloov pauv rau qee cov noob lossis thaj chaw ntawm genome.

Ib yam li ib tug yuav nug, lub hom phiaj ntawm qhov chaw qhia mutagenesis yog dab tsi?

Qhov chaw - qhia mutagenesis yog ib txoj hauv kev molecular biology uas yog siv los ua qhov tshwj xeeb thiab txhob txwm hloov pauv mus rau DNA ib ntu ntawm cov noob thiab txhua yam khoom siv noob.

Tsis tas li ntawd, koj ua li cas tsim ib qhov chaw qhia mutagenesis primer? Ob tug primers yuav tsum tau tsim nyob rau hauv opposite lus qhia nrog lawv 5 'kawg nyob ib sab ntawm lub cheeb tsam yuav tsum tau muab tshem tawm. Cov primers tuaj yeem ua tau 100% ntxiv rau plasmid ib ntus lossis tuaj yeem muaj qhov tsis sib xws thiab / lossis kev ntxig yog xav tau. Qhov sib lawv liag yuav tsum tau muab ntxiv rau 5' kawg ntawm qhov mutagenic primer.

Ntawm no, qhov chaw qhia mutagenesis ua li cas?

Qhov chaw - qhia mutagenesis (SDM) yog ib txoj hauv kev los tsim cov kev hloov pauv tshwj xeeb hauv ob chav plasmid DNA. Txhawm rau kawm txog kev hloov pauv hauv cov haujlwm protein uas tshwm sim los ntawm DNA kev tswj hwm. Txhawm rau xaiv lossis tshuaj ntsuam kev hloov pauv (ntawm DNA, RNA lossis qib protein) uas muaj cov khoom xav tau.

PCR mutagenesis yog dab tsi?

PCR mutagenesis yog ib txoj hauv kev los tsim qhov chaw qhia mutagenesis . Txoj kev no tuaj yeem tsim cov kev hloov pauv (piv txwv, ntxig, thiab tshem tawm) los ntawm ob npaug-stranded plasmid yam tsis tas yuav tsum muaj subcloning rau hauv M13-based bacteriophage vectors thiab rau ssDNA cawm.

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