Qhov sib faib coefficient ntawm 1 txhais li cas?
Qhov sib faib coefficient ntawm 1 txhais li cas?

Video: Qhov sib faib coefficient ntawm 1 txhais li cas?

Video: Qhov sib faib coefficient ntawm 1 txhais li cas?
Video: Npau suav pom ntshav txhais li cas? 2024, Kaum ib hlis
Anonim

Hauv kev tshawb fawb tshuaj thiab kws tshuaj, ob theem feem ntau yog cov kuab tshuaj. Feem ntau, ib ntawm cov kuab tshuaj yog dej, hos qhov thib ob yog hydrophobic, xws li 1 - octanol. Li no lub muab faib coefficient ntsuas seb hydrophilic ("dej-hlub") los yog hydrophobic ("dej-ntshai") cov tshuaj yog tshuaj.

Ib yam li ntawd, nws tau nug, puas yog qhov sib faib siab coefficient zoo dua?

chav ntsuas ntsuas hu ua muab faib coefficient . Qhov ntau dua qhov solubility ntawm ib yam khoom, lub siab dua nws muab faib coefficient , thiab cov siab dua tus muab faib coefficient , cov siab dua lub permeability ntawm daim nyias nyias rau cov khoom tshwj xeeb.

Tsis tas li ntawd, qhov sib faib coefficient ntawm benzoic acid yog dab tsi? Cov muab faib coefficient yog cov kev faib tawm ntawm solute nyob rau hauv ob immiscible kua. Nws yog cov kev ua ntawm solute nkag mus rau hauv cov organic theem lossis aqueous theem uas tau piav qhia los ntawm Muab faib Txoj cai los ntawm kev noj benzoic acid hauv benzene thiab dej, uas tau piav qhia tias benzoic acid muaj nyob rau hauv daim ntawv dimeric03. ?? = √ C org.

Ua li no, logD txhais li cas?

logD yog a log Kev faib tawm ntawm cov tshuaj sib xyaw ntawm lipid thiab aqueous theem. Qhov nrov tshaj plaws lipid theem yog octanol. LogP yog sib npaug rau logD rau cov tsis-ionisable tebchaw thiab sawv cev rau qhov muab faib ntawm daim ntawv nruab nrab rau ionizable tebchaw (thiab, li no, yog virtual, unmeasurable, khoom).

Dab tsi yog units ntawm partition coefficient?

A muab faib coefficient yog qhov piv ntawm cov concentration ntawm cov khoom hauv ib qho nruab nrab lossis theem (C1) mus rau qhov concentration nyob rau theem ob (C2) thaum ob qhov concentrations ntawm equilibrium; uas yog, muab faib coefficient = (C1/C2)sib npaug. Cov units ntawm C1 thiab C2 tej zaum yuav txawv.

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