Video: Puas yog tib neeg muaj pyruvate decarboxylase?
2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36
Nws yog tsim los ntawm kwv yees li 96 subunits koom ua peb lub luag haujlwm enzymes hauv tib neeg : 20-30 daim pyruvate ua dehydrogenase E1 tivthaiv, 60 daim ntawv luam ntawm pyruvate ua dehydrogenase E2 tivthaiv, thiab 6 daim ntawv luam ntawm dihydrolipoyl dehydrogenase (E3).
Yog li ntawd, pyruvate decarboxylase ua dab tsi?
Pyruvate decarboxylase yog homotetrameric enzyme (EC 4.1. 1.1) uas catalyses decarboxylation ntawm pyruvic acid rau acetaldehyde thiab carbon dioxide nyob rau hauv lub cytoplasm ntawm prokaryotes, thiab nyob rau hauv cytoplasm thiab mitochondria ntawm eukaryotes.
Ib sab saum toj, qhov twg pyruvate decarboxylation tshwm sim? Yog lawm, pyruvate ua oxidation tshwm sim nyob rau hauv mitochondrial matrix ntawm eukaryotic hlwb. Sai li sai tau pyruvate ua nkag mus rau mitochondrial matrix hauv eukaryotes, nws yog oxidatively decarboxylated (nrog kev pab ntawm enzyme Pyruvate DeHydrogenase, PDH) los tsim Acetyl CoA (uas yog tom qab ntawd pub dawb los ua lub substrate hauv Krebs cycle).
Ib yam li ntawd, nws tau nug, puas yog pyruvate dehydrogenase tib yam li pyruvate decarboxylase?
Pyruvate decarboxylase yog homotetrameric enzyme (EC 4.1. Cov enzyme no yuav tsum tsis txhob yuam kev rau cov enzyme uas tsis muaj kev cuam tshuam. pyruvate dehydrogenase , ib qho oxidoreductase (EC 1.2. 4.1), uas catalyzes oxidative decarboxylation ntawm pyruvate ua rau acetyl-CoA.
Yuav ua li cas tshwm sim thaum lub sij hawm pyruvate decarboxylation?
Pyruvate decarboxylation los yog pyruvate ua oxidation, tseem hu ua txuas cov tshuaj tiv thaiv, yog kev hloov dua siab tshiab ntawm pyruvate ua mus rau acetyl-CoA los ntawm cov enzyme complex pyruvate ua dehydrogenase complex. Lub zog-tsim ions thiab molecules xws li amino acids thiab carbohydrates nkag mus rau lub voj voog Krebs li acetyl coenzyme A thiab oxidize. hauv lub voj voog.
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