Qhov twg hauv mitochondria puas pyruvate oxidation tshwm sim?
Qhov twg hauv mitochondria puas pyruvate oxidation tshwm sim?

Video: Qhov twg hauv mitochondria puas pyruvate oxidation tshwm sim?

Video: Qhov twg hauv mitochondria puas pyruvate oxidation tshwm sim?
Video: Tus Twg Nyob Hauv Koj Siab - Xanakee 2024, Kaum ib hlis
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Pyruvate yog tsim los ntawm glycolysis hauv cytoplasm, tab sis pyruvate oxidation tshwm sim nyob rau hauv lub mitochondrial matrix (hauv eukaryotes). Yog li, ua ntej cov tshuaj tiv thaiv tuaj yeem pib, pyruvate ua yuav tsum nkag rau hauv mitochondrion , hla nws daim nyias nyias thiab tuaj txog ntawm matrix.

Hais txog qhov no, pyruvate nkag mus rau hauv mitochondria li cas?

Kev thauj mus los ntawm pyruvate nyob rau hauv mitochondria yog los ntawm kev thauj cov protein pyruvate ua translocase. Pyruvate translocase thauj pyruvate ua nyob rau hauv ib tug symport zam nrog ib tug proton, thiab li no yog active, siv zog. Thaum nkag mus rau lub mitochondria , cov pyruvate ua yog decarboxylated, tsim acetyl-CoA.

Ib sab saum toj no, qhov twg oxidative phosphorylation tshwm sim? Oxidative phosphorylation tshwm sim nyob rau hauv lub puab mitochondrial membrane, nyob rau hauv sib piv nrog rau feem ntau ntawm cov tshuaj tiv thaiv ntawm citric acid voj voog thiab fatty acid. oxidation , uas coj qhov chaw nyob rau hauv lub matrix.

Hauv kev hwm rau qhov no, yuav ua li cas rau pyruvate hauv mitochondria?

Yog lawm, pyruvate ua oxidation tshwm sim hauv mitochondrial matrix ntawm eukaryotic hlwb. Sai li sai tau pyruvate ua nkag rau hauv mitochondrial matrix nyob rau hauv eukaryotes, nws yog oxidatively decarboxylated (nrog kev pab los ntawm cov enzymes. Pyruvate DeHydrogenase, PDH) los tsim Acetyl CoA (uas yog tom qab ntawd pub dawb los ua lub substrate hauv Krebs cycle).

Puas tuaj yeem pyruvate nkag mus rau mitochondria?

Thaum lub sij hawm ua pa metabolism, pyruvate tuaj yeem nkag mus rau mitochondria los ntawm ib tus neeg nqa khoom tshwj xeeb (4, 5) thiab decarboxylated thiab oxidized rau hauv acetyl-CoA los ntawm pyruvate ua dehydrogenase, multienzyme complex nyob rau hauv lub matrix (6).

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