Video: Log P tus nqi ntawm cov tshuaj yog dab tsi?
2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36
Lipophilicity plays lub luag haujlwm tseem ceeb hauv tshuaj discovery thiab compound design. Lub lipophilicity ntawm cov organic compound tuaj yeem piav qhia los ntawm kev faib coefficient, logP , uas tuaj yeem txhais tau tias yog qhov sib piv ntawm cov concentration ntawm unionized compound ntawm equilibrium ntawm cov organic thiab aqueous theem.
Ib yam li ntawd, nws tau nug tias, tus nqi log p yog dab tsi?
Cov logP nqi yog ib tug tas mus li txhais raws li hauv qab no: LogP = log10 (Partition Coefficient) Partition Coefficient, P = [organic]/[aqueous] Qhov twg qhia qhov concentration ntawm solute hauv cov organic thiab aqueous muab faib. LogP = 1 txhais tau hais tias muaj 10: 1 muab faib hauv Organic: Aqueous phases.
Tsis tas li ntawd, lipophilicity ntawm cov tshuaj yog dab tsi? Lipophilicity txhais tau tias yog affinity ntawm a tshuaj rau ib puag ncig lipid. Lipophilicity tuaj yeem ntsuas los ntawm kev faib tawm ntawm a tshuaj nruab nrab ntawm cov organic theem, uas feem ntau yog n-octanol pre-saturated nrog dej, thiab lub aqueous theem, uas feem ntau yog dej pre-saturated nrog n-octanol.
Kuj nug, qhov sib txawv ntawm log P thiab log D yog dab tsi?
LogD yog ib qho kev faib coefficient dav siv los ntsuas qhov lipophilicity ntawm ionizable tebchaw, qhov chaw faib ua haujlwm ntawm pH. Rau cov tsis-ionizable compounds LogP = LogD thoob plaws pH ntau yam, whereas rau ionizable compounds LogD coj mus rau hauv tus account qhov muab faib ntawm ob qho tib si ionized thiab non-ionized daim ntawv.
Kev siv cov ntaub ntawv log yog dab tsi?
Cov ntaub ntawv teev cia yog ib cov ntaub ntawv uas khaws cov npe ntawm cov xwm txheej, txheej txheem, cov lus thiab kev sib txuas lus nruab nrab ntawm ntau yam kev sib txuas lus software kev siv thiab lub operating system.
Pom zoo:
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