Video: Qhov twg yog lub hauv paus chiv keeb ntawm Alu insertion?
2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36
Lawv yog muab los ntawm lub me me cytoplasmic 7SL RNA, ib feem ntawm lub teeb pom kev zoo particle. Alu cov ntsiab lus tau txais kev cawmdim heev nyob rau hauv primate genomes thiab keeb kwm nyob rau hauv lub genome ntawm ib tug yawm txiv ntawm Supraprimates.
Dhau li ntawm no, lub hauv paus chiv keeb ntawm ALU sine yog dab tsi?
Alu Cov ntsiab lus yog poj koob yawm txwv muab los ntawm 7SL RNA gene [35, 36]. Txawm hais tias cov ntsiab lus ntawm lub keeb kwm tsis paub, nws zoo nkaus li tias qhov tsis muaj txiaj ntsig retrotransposon tau tsim los ntawm kev tshem tawm version ntawm 7SL RNA noob qee zaum ua ntej primate / nas evolutionary divergence.
Ib tug kuj nug, ALU noob nyob qhov twg? Ntawm peb billion lub hauv paus hauv tib neeg genome, kwv yees li 10% yog tsim los ntawm ib lab luam ntawm ib qho quasi-randomly tso, ~ 300-bp primate-specific ib ntus hu ua Alu element . Tib neeg FXN noob , nyob ntawm caj npab ntev ntawm chromosome 9, muaj qhov sib koom tsis zoo ntawm 39 Alu cov ntsiab lus tau muab tso rau hauv ntau qhov chaw.
Tom qab ntawd, Alu insertion yog dab tsi?
Alu cov ntsiab lus yog ib hom "dav gene," los yog cov khoom hloov pauv (TE), uas tsuas muaj nyob hauv cov tsiaj txhu xwb. Zoo li tag nrho cov TEs, lawv yog cov sib cais DNA uas txav mus los, lossis "dhia," los ntawm ib qho chaw ntawm genome mus rau lwm qhov, qee zaum ntxig cov ntawv luam ntawm lawv tus kheej ncaj qha rau hauv nruab nrab ntawm cov protein-coding noob.
Dab tsi yog Alu ib ntus ntawm chromosome 16?
Alu yog ib qho piv txwv ntawm lub npe hu ua "dhia gene" - transposable DNA ib ntus uas "reproduces" los ntawm kev luam nws tus kheej thiab tso rau hauv qhov chaw tshiab chromosome. Alu yog cais raws li ib tug retroposon, vim hais tias nws yog xav kom tus retrovirus enzyme reverse transcriptase (rt) enzyme ua ib tug mobile luam ntawm nws tus kheej.
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