Kev ua haujlwm ntawm HIV 1 thim rov qab transcriptase yog dab tsi?
Kev ua haujlwm ntawm HIV 1 thim rov qab transcriptase yog dab tsi?

Video: Kev ua haujlwm ntawm HIV 1 thim rov qab transcriptase yog dab tsi?

Video: Kev ua haujlwm ntawm HIV 1 thim rov qab transcriptase yog dab tsi?
Video: Tshuaj theem vim li cas thiaj tau nqi ?/ Siv kho mob dab tsi?/paris polyphylla use for? 2024, Kaum ib hlis
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Cov HIV - 1 rov qab transcriptase enzyme yog lub luag haujlwm rau luam ib leeg-stranded viral RNA genome rau hauv ob-stranded DNA (Sarafianos li al, 2001). Cov DNA tsim tshiab tuaj yeem muab tso rau hauv tus tswv tsev genome; tus tswv tsev feem ntau yog tib neeg nyob rau hauv rooj plaub ntawm HIV.

Hais txog qhov no, kev ua haujlwm ntawm kev rov qab transcriptase hauv HIV yog dab tsi?

HIV /AIDS Glossary Ib zaug hauv CD4 cell, HIV tso tawm thiab siv rov qab transcriptase (ib HIV enzyme) los hloov nws cov khoom siv caj ces- HIV RNA-rau HIV DNA. Kev hloov dua siab tshiab ntawm HIV RNA rau HIV DNA tso cai HIV nkag mus rau CD4 cell nucleus thiab ua ke nrog cov khoom siv ntawm tes-cell DNA.

Tsis tas li ntawd, rov qab transcriptase ua haujlwm li cas? A rov qab transcriptase (RT) yog ib qho enzyme uas siv los tsim cov DNA ntxiv (cDNA) los ntawm RNA template, ib qho txheej txheem hu ua rov qab transcription . Hauv cov kab mob retroviruses thiab retrotransposons, cDNA no tuaj yeem ua ke rau hauv tus tswv tsev genome, los ntawm cov ntawv luam RNA tshiab tuaj yeem ua los ntawm tus tswv-cell. kev sau ntawv.

Hais txog qhov no, dab tsi yog lub luag haujlwm ntawm thim rov qab transcriptase hauv kev kuaj kab mob HIV?

Replication: Ib zaug HIV khi rau ib lub cell, nws nkaum HIV DNA nyob rau hauv lub cell DNA: qhov no hloov lub cell mus rau hauv ib hom HIV Hoobkas. Tus kab mob retrovirus yog tsim los ntawm RNA tsis yog DNA. Lawv muaj ib qho enzyme hu ua rov qab transcriptase uas muab lawv cov cuab yeej tshwj xeeb ntawm kev sau lawv RNA rau hauv DNA tom qab nkag mus rau hauv lub cell.

Integrase ua dab tsi hauv HIV?

Kev sib xyaw ua ke . Ib qho enzyme pom hauv HIV (thiab lwm yam retroviruses). HIV siv kev sib xyaw mus ntxig (integrate) nws cov kab mob DNA rau hauv DNA ntawm tus tswv tsev CD4 cell.

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