Video: Dab tsi yog qhov txawv ntawm kev kho tsis sib haum thiab nucleotide excision kho quizlet?
2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36
Dab tsi yog qhov qhov sib txawv ntawm kev kho mismatch thiab nucleotide excision kho ? Hauv kho tsis sib haum , ib nucleotide yog hloov, whereas nyob rau hauv nucleotide excision kho ob peb nucleotides hloov. Hauv kho tsis sib haum , ntau nucleotides hloov, whereas nyob rau hauv nucleotide excision kho nws tsuas yog ib qho xwb.
Ntawm no, qhov tseeb txhais ntawm nucleotide excision kho yog dab tsi?
Nucleotide excision kho yog a kho DNA tshuab. Nucleotide excision kho (NER) yog qhov tseem ceeb tshwj xeeb kev txiav txim mechanism uas tshem tawm DNA kev puas tsuaj los ntawm ultraviolet lub teeb (UV). UV DNA kev puas tsuaj ua rau loj heev DNA adducts - cov adducts feem ntau yog thymine dimers thiab 6, 4-photoproducts.
Qhov thib ob, yuav ua li cas thaum kho nucleotide? Hauv nucleotide excision kho (NER), cov hauv paus puas raug txiav tawm hauv ib txoj hlua ntawm nucleotides , thiab hloov nrog DNA raws li qhia los ntawm cov qauv tsis raug puas tsuaj. Qhov no kho system yog siv los tshem tawm pyrimidine dimers tsim los ntawm UV hluav taws xob zoo li nucleotides hloov kho los ntawm bulk chemical adducts.
Ib yam li ib tug yuav nug, hom kev hloov DNA uas feem ntau kho los ntawm nucleotide excision kho?
Nucleotide excision kho yog thawj kho system rau bulky DNA adducts xws li cyclobutane pyrimidine dimer (PyrPyr), (6–4) photoproduct, benzo[a]pyrene-guanine adduct, acetylaminofluorene-guanine (AAF-G), thiab cisplatin-d (GpG) diadduct.
Qhov kawg tshwm sim ntawm lub hauv paus excision kho yog dab tsi?
Base excision kho (BER) kho me me puag cov kab mob uas tsis tseem ceeb distort lub DNA helix qauv. Xws li kev puas tsuaj feem ntau tshwm sim los ntawm deamination, oxidation, los yog methylation (Daim duab. Lindahl tshawb nrhiav ib qho enzyme uas yuav ua rau genomic uracil tshwm sim los ntawm cytosine deamination.
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