Video: PAMPs immunology yog dab tsi?
2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36
Pathogen-associated molecular qauv los yog PAMPs yog cov molecules sib koom los ntawm cov pab pawg ntawm cov kab mob sib xws uas yog qhov tseem ceeb rau kev ciaj sia ntawm cov kab mob no thiab tsis pom muaj cuam tshuam nrog cov kab mob mammalian. PAMPs thiab DAMPs khi rau cov qauv-pom zoo receptors lossis PRRs cuam tshuam nrog lub cev hlwb los txhawb kev tiv thaiv innate.
Kuj kom paub yog, piv txwv ntawm PAMPs yog dab tsi?
Qhov zoo tshaj plaws-paub piv txwv ntawm PAMPs suav nrog lipopolysaccharide (LPS) ntawm cov kab mob gram-negative; lipoteichoic acids (LTA) ntawm cov kab mob gram-zoo; peptidoglycan; lipoproteins tsim los ntawm palmitylation ntawm N-terminal cysteine ntawm ntau cov kab mob cell phab ntsa proteins; lipoarabinomanan ntawm mycobacteria; ob-stranded RNA
Ib yam li ntawd, PAMPs nyob qhov twg? Mammalian TLRs paub cov kab mob cuam tshuam nrog cov qauv molecular ( PAMPS ). Thaum TLRs 1, 2, 4, thiab 6 nyob rau ntawm lub xov tooj ntawm tes, TLRs uas paub txog txawv teb chaws nucleic acids (TLRs 3, 7, 8, thiab 9) yog nyob rau hauv lub endoplasmic reticulum (ER) thiab / los yog endosomes [14] (Daim duab 13.3).
Raws li, PAMPs thiab PRRs yog dab tsi?
PAMPs thiab PRRs . Cytokines yog soluble peptides uas ua rau kev ua kom muaj zog, kev loj hlob thiab kev sib txawv ntawm cov hlwb ntawm lub cev tiv thaiv kab mob. Adaptive immunity paub txog ntau yam tsis kawg ntawm antigens los ntawm ntau lab ntawm cov cell-nto receptors.
Puas yog PAMPs antigens?
antigen . Ib antigen yog ib qho molecule uas txhawb kev tiv thaiv kab mob. Pathogen-associated molecular qauv ( PAMPs ) yog cov kab mob me me uas tsis tu ncua pom ntawm cov kab mob uas tau lees paub los ntawm Tus Xov Tooj Zoo li receptors (TLRs) thiab lwm yam qauv-paub cov receptors (PRRs).
Pom zoo:
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