Lub pharmacological tseem ceeb ntawm enantiomers yog dab tsi?
Lub pharmacological tseem ceeb ntawm enantiomers yog dab tsi?

Video: Lub pharmacological tseem ceeb ntawm enantiomers yog dab tsi?

Video: Lub pharmacological tseem ceeb ntawm enantiomers yog dab tsi?
Video: Txojsia Tseem Ceeb Heev Txhob Cia Sijhawm Dhau Mus 2024, Kaum ib hlis
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Qhov tseem ceeb ntawm tshuaj cov enantiomers hauv kev kho mob kws tshuaj . Williams K, Lee E. Qhov kev txiav txim asymmetry ntawm cov roj ntsha macromolecules tso cai rau lawv sib txawv ntawm cov isomers optical ntawm monomeric substrates.

Tsis tas li ntawd, vim li cas enantiomers tseem ceeb?

Lub molecule tau hais tias yog chiral yog tias nws tuaj yeem muaj nyob ua isomers (hu ua cov enantiomers ) uas yog nonsuperimposable iav dluab ntawm ib leeg. Qhov no yog tseem ceeb vim hais tias cov lus teb ntawm cov kab mob mus rau ib qho molecule feem ntau nyob ntawm seb qhov molecule haum rau ib qho chaw tshwj xeeb ntawm ib qho receptor molecule hauv lub cev.

Kuj Paub, kev siv isomerism yog dab tsi? Tshuaj isomerism tau qhib lub sijhawm tshiab ntawm kev txhim kho tshuaj. Tam sim no, kev paub txog isomerism tau pab peb hauv kev qhia txog kev nyab xeeb thiab siv tau zoo dua lwm yam tshuaj tshiab ntawm cov tshuaj tshiab thiab cov tshuaj uas twb muaj lawm. Ntau cov tshuaj uas twb muaj lawm tau mus chiral hloov piv txwv li, hloov ntawm racemic sib tov mus rau ib qho ntawm nws isomers.

Hais txog qhov no, vim li cas stereochemistry tseem ceeb hauv pharmacology?

Stereochemistry suav nrog txoj hauv kev los txiav txim siab thiab piav txog cov kev sib raug zoo no; Cov txiaj ntsig ntawm lub cev lossis cov khoom siv lom neeg cov kev sib raug zoo no cuam tshuam rau cov molecules hauv nqe lus nug thiab yuav ua li cas cov kev sib raug zoo no cuam tshuam rau cov reactivity ntawm molecules hauv nqe lus nug (dynamic stereochemistry ).

Vim li cas cov teebmeem ntawm enantiomers txawv li ntawd?

Enantiomers nquag muaj ntau txawv Kev ua haujlwm lom neeg vim lawv khi rau receptors hauv lub cev uas kuj yog chiral. Enantiomers kuj txawv ntawm txoj kev uas lawv cuam tshuam lub teeb polarized. Ordinary teeb muaj lub teeb vibrating uniformly nyob rau hauv tag nrho cov txawv dav hlau perpendicular mus rau cov kev taw qhia nws tsiv.

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