MicroRNA siRNA cuam tshuam li cas cov noob qhia?
MicroRNA siRNA cuam tshuam li cas cov noob qhia?

Video: MicroRNA siRNA cuam tshuam li cas cov noob qhia?

Video: MicroRNA siRNA cuam tshuam li cas cov noob qhia?
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Gene Silence mediated los ntawm miRNA

Qhov sib txawv loj ntawm siRNAs thiab miRNAs yog tias tus qub inhibit qhov kev qhia ntawm ib lub hom phiaj tshwj xeeb mRNA thaum kawg regulate lub kev qhia ntawm ntau mRNAs. Lub cev tseem ceeb ntawm cov ntaub ntawv tam sim no faib cov miRNAs ua RNAi molecules.

Tom qab ntawd, ib tug kuj yuav nug, ua li cas miRNA thiab siRNA tswj gene qhia?

miRNAs ( microRNAs ) yog luv tsis-coding RNAs uas tswj gene qhia post-transcriptionally. Lawv feem ntau khi rau 3 '-UTR (cheeb tsam tsis txhais lus) ntawm lawv lub hom phiaj mRNAs thiab ua rau cov protein ntau los ntawm kev ua kom tsis muaj zog. mRNA thiab translational silence.

Ib tug kuj yuav nug, dab tsi yog lub luag haujlwm ntawm siRNA thiab miRNA? Lub ntsiab muaj nuj nqi ntawm siRNA yog los tswj genome kev ncaj ncees tawm tsam txawv teb chaws RNA molecules thaum lub miRNA ua hauj lwm raws li regulators ntawm endogenous noob. Ib leeg siRNA khi rau ib leeg mRNA thaum lub miRNA muaj ntau qhov chaw ua haujlwm zoo ib yam nrog rau mRNA sib txawv.

Tom qab ntawd, siRNA cuam tshuam li cas ntawm cov noob qhia?

Lub complex silences tej gene qhia los ntawm cleaving mRNA molecules coding lub hom phiaj noob . Ces, lub siRNA scans rau thiab qhia RISC kom ua tiav cov kab ke sib luag ntawm mRNA molecules. Lub cleavage ntawm lub mRNA Cov molecules xav tias yuav catalyzed los ntawm Piwi domain ntawm Argonaute proteins ntawm RISC.

RNAi tswj cov kev qhia gene li cas?

Lub sij hawm RNA cuam tshuam ( RNAi ) tau coined los piav txog lub cellular mechanism uas siv cov cov gene tus kheej DNA sequence ntawm noob kom tua nws, ib txheej txheem uas cov kws tshawb fawb hu ua silence. Cov khoom me me no, hu ua me me cuam tshuam RNAs ( siRNA ), khi rau cov proteins los ntawm tsev neeg tshwj xeeb: cov proteins Argonaute.

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