Tyrosine kinase receptors nyob qhov twg?

2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36

Teeb liab mechanisms downstream ntawm activated tyrosine kinase receptors . Feem ntau, cov chaw nrhiav neeg ua haujlwm phosphotyrosine hauv RTKs yog nyob nyob rau hauv lub C-terminal tus Tsov tus tw tus neeg txais kev pab , lub cheeb tsam juxtambrane, los yog kinase ntxig cheeb tsam.

Tsis tas li ntawd, qhov twg receptor tyrosine kinases nyob hauv lub cell?

Protein tyrosine kinases yog cov enzymes uas muaj peev xwm ntxiv ib pab pawg phosphate rau tyrosines tshwj xeeb ntawm cov hom phiaj protein. A tyrosine kinase receptors (RTK) yog a tyrosine kinase nyob ntawm lub cellular membrane thiab yog qhib los ntawm kev khi ntawm ib tug ligand ntawm nws extracellular domain.

Ib sab saum toj no, tus receptor tyrosine kinase phosphorylate nws tus kheej li cas? RTKs yog transmembrane protein ntau cov receptors uas pab cov cell cuam tshuam nrog lawv cov neeg zej zog hauv cov ntaub so ntswg. Tshwj xeeb, kev khi ntawm lub teeb liab molecule nrog RTK activates tyrosine kinase nyob rau hauv lub cytoplasmic tus Tsov tus tw tus neeg txais kev pab.

Hauv qhov no, kev ua haujlwm ntawm tyrosine kinase receptors yog dab tsi?

Cov receptor tyrosine kinases ua haujlwm nyob rau hauv transmembrane signaling, whereas tyrosine kinases nyob rau hauv lub cell muaj nuj nqi nyob rau hauv lub teeb liab transduction mus rau lub nucleus. Tyrosine kinase Kev ua haujlwm hauv lub nucleus suav nrog kev tswj xyuas lub voj voog ntawm tes thiab cov khoom ntawm cov khoom siv hloov pauv.

Yuav ua li cas receptor tyrosine kinases hloov lub teeb liab?

Teeb liab transduction Los ntawm ntau yam txhais tau tias, extracellular ligand binding yuav feem ntau ua rau lossis ruaj khov tus neeg txais kev pab dimerization. Qhov no tso cai rau ib tyrosine nyob rau hauv cytoplasmic feem ntawm txhua tus neeg txais kev pab monomer rau yuav trans-phosphorylated los ntawm nws tus khub tus neeg txais kev pab ,pab a teeb liab los ntawm plasma membrane.