Yuav ua li cas koj txiav txim siab lub active site ntawm ib tug enzyme?
Yuav ua li cas koj txiav txim siab lub active site ntawm ib tug enzyme?

Video: Yuav ua li cas koj txiav txim siab lub active site ntawm ib tug enzyme?

Video: Yuav ua li cas koj txiav txim siab lub active site ntawm ib tug enzyme?
Video: TUDev Tech Talk с профессором Борой Озкан - Финтех и будущее финансов 2024, Hlis ntuj nqeg
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Kev Taw Qhia. Active cov chaw yog cov cheeb tsam feem ntau nyob rau saum npoo ntawm cov enzymes tshwj xeeb ua qauv los ntawm xwm thaum lub sij hawm evolution uas yog catalyze ib qho tshuaj tiv thaiv los yog lub luag hauj lwm rau substrate kev khi . Cov qhov chaw nquag tuaj yeem ua tau, yog li ntawd, muab faib ua ob ntu, uas suav nrog catalytic site thiab substrate khi qhov chaw (1).

Tsis tas li ntawd, koj yuav nrhiav tau qhov chaw nquag ntawm ib qho enzyme li cas?

Hauv biology, lub qhov chaw nquag yog thaj tsam ntawm ib enzyme qhov twg substrate molecules khi thiab raug tshuaj lom neeg cov tshuaj tiv thaiv. Cov qhov chaw nquag muaj cov residues uas tsim ib ntus daim ntawv cog lus nrog lub substrate (binding qhov chaw ) thiab residues uas catalyze cov tshuaj tiv thaiv ntawm cov substrate (catalytic qhov chaw ).

Qhov thib ob, lub luag haujlwm ntawm qhov chaw ua haujlwm ntawm enzyme yog dab tsi? Lub substrate yog cov khoom los yog cov molecule uas yog ib qho enzyme ua haujlwm . Cov hnab ris no muaj cov qhov chaw nquag , uas yog thaj tsam ntawm ib enzyme qhov twg lub substrate khi thiab cov tshuaj tiv thaiv yuav siv sij hawm qhov chaw . Hauv qhov chaw nquag , cov amino acids enzyme protein yuav khi rau lub substrate.

Kuj kom paub yog, koj ua li cas thiaj nrhiav tau qhov chaw nquag ntawm cov protein?

Saib cov no cov chaw nquag , zais tag nrho cov khoom thauj khoom rau hauv PyMol los ntawm kev siv cov lus txib "hide". Sawv cev tag nrho protein ntau nrog tus sawv cev saum npoo, teeb tsa nrog 50% pob tshab. Xaiv qhov khoom protein ntau molecule, qhia? nto puv tag nrho protein ntau molecule rau saum npoo sawv cev.

Dab tsi amino acids feem ntau pom nyob rau hauv lub chaw ua haujlwm?

beta-Alanine - Tsuas yog ib txwm tshwm sim beta amino acid . Arginine - Amino acid feem ntau siv rau ntawm cov chaw nquag ntawm enzymes. Asparagine - Amide derivative ntawm aspartic kua qaub . Aspartic Acid - Qhov tseem ceeb nruab nrab ntawm citric kua qaub lub voj voog.

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