IMP thiab GMP yog dab tsi?
IMP thiab GMP yog dab tsi?

Video: IMP thiab GMP yog dab tsi?

Video: IMP thiab GMP yog dab tsi?
Video: qhov ncauj qhia tau neeg Tus YAM NTXWV thiab TXOJ HMOO 2024, Kaum ib hlis
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Inosine 5'-monophosphate IMP ) yog ib ceg taw tes uas tuaj yeem ua rau AMP lossis GMP (Daim duab 22.6). Yog li, synthesis ntawm txhua nucleotide yog inhibited los ntawm cov khoom kawg ntawm txhua txoj kev ( GMP los yog AMP), thiab txhua ceg txoj kev sib txuas lus xav tau lub zog los ntawm lwm cov nucleoside triphosophate, ATP lossis GTP.

Ib yam li ntawd, koj tuaj yeem nug, IMP biochemistry yog dab tsi?

Inosinic acid los yog inosine monophosphate ( IMP ) yog ib qho nucleoside monophosphate. Cov derivatives tseem ceeb ntawm inosinic acid suav nrog purine nucleotides pom nyob rau hauv nucleic acids thiab adenosine triphosphate, uas yog siv los khaws cov tshuaj zog hauv cov leeg thiab lwm cov ntaub so ntswg.

Tom qab ntawd, lo lus nug yog, AMP puas yog purine? Ntxiv nrog rau lub luag haujlwm tseem ceeb ntawm cov purines (adenine thiab guanine) hauv DNA thiab RNA, cov purines tseem yog cov khoom tseem ceeb hauv ntau lwm yam tseem ceeb biomolecules, xws li ATP, GTP, cyclic AMP , NADH, thiab coenzyme A. Purine (1) nws tus kheej, tsis tau pom nyob rau hauv qhov, tab sis nws tuaj yeem tsim los ntawm cov organic synthesis.

Ib yam li ntawd, nws tau nug, dab tsi yog qhov tsuas yog enzyme hauv purine synthesis txoj kev tswj hwm los ntawm AMP GMP thiab IMP?

Lub adenylosuccinate lyase hauv qhov no txoj kev yog tib yam enzyme uas catalyzes cov tshuaj tiv thaiv 8 ntawm de novo purine biosynthesis raws li tau piav saum toj no. Ob tug cov enzymes hauv IMP rau GMP txoj kev yog IMP dehydrogenase (IMPDH) thiab GMP synthetase. Tib neeg nthuav tawm ob lub noob IMPDH pom tias yog IMPDH1 thiab IMPDH2.

Qhov twg purine catabolism tshwm sim?

Uric acid metabolism tshwm sim nyob rau hauv peroxisome los ntawm urate oxidase (los yog los ntawm catalase) thiab los ntawm ob intermediates, tsim los ntawm ob lwm yam enzymes, ua rau (S)-allantoin. Nyob ntawd ua tau ua genetic alterations nyob rau hauv cov noob rau cov enzymes uas ua tau account rau siab uric acid thiab cov kev tshawb fawb no tab tom pib.

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