Muaj pes tsawg cov tshuaj chiral?

Video: Muaj pes tsawg cov tshuaj chiral?

2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36

Tag nrho cov proteins, enzymes, amino acids, carbohydrates, nucleosides thiab ntau alkaloids thiab cov tshuaj hormones yog chiral tshuaj sib xyaw. Hauv kev lag luam tshuaj, 56% ntawm cov tshuaj tam sim no siv tau chiral cov khoom lag luam thiab 88% ntawm cov khoom kawg tau ua lag luam raws li cov neeg sib tw uas muaj kev sib xyaw ua ke ntawm ob enantiomers (3-5).

Tom qab ntawd, ib tug kuj yuav nug, dab tsi yog tshuaj chiral?

Ib qho enntiopure tshuaj yog ib qho tshuaj uas muaj nyob rau hauv ib daim ntawv tshwj xeeb enantiomeric. Feem ntau cov roj ntsha molecules (cov protein, suab thaj, thiab lwm yam) muaj nyob hauv ib qho ntawm ntau chiral cov ntaub ntawv, yog li txawv enantiomers ntawm a tshuaj chiral molecule khi txawv (lossis tsis tag nrho) rau lub hom phiaj receptors.

Ib sab saum toj, pes tsawg chiral carbons nyob hauv ibuprofen? Ibuprofen , zoo li lwm yam 2-arylpropionate derivatives (xws li ketoprofen, flurbiprofen, naproxen, thiab lwm yam), chiral carbon nyob rau hauv Î±- txoj hauj lwm ntawm propionate moiety. Raws li xws li, muaj ob ua tau enantiomers ntawm ibuprofen , nrog rau lub peev xwm rau cov teebmeem lom neeg sib txawv thiab cov metabolism hauv txhua tus enantiomer.

Hauv qhov no, vim li cas chirality tseem ceeb hauv tshuaj?

Ib tug enantiomer ntawm a tshuaj chiral tej zaum yuav yog ib yam tshuaj rau cov kab mob tshwj xeeb whereas; Lwm enantiomer ntawm cov molecule tej zaum yuav tsis tsuas yog inactive tab sis kuj yuav ua rau lom. Li no Chirality play ib qhov tseem ceeb luag hauj lwm hauv tshuaj . Synthesising compound raws li ib tug enantiomer yog tseem ceeb heev nyob rau hauv kev tsim thiab synthesis ntawm tshuaj.

Dab tsi yog qhov tseem ceeb ntawm chirality?

Qhov tseeb, ntau ntawm cov molecules uas tsim los ntawm cov kab mob ua rau muaj kev cuam tshuam tshwj xeeb. Qhov no yog tseem ceeb vim hais tias cov lus teb ntawm cov kab mob mus rau ib qho molecule feem ntau nyob ntawm seb qhov molecule haum rau ib qho chaw tshwj xeeb ntawm ib qho receptor molecule hauv lub cev.

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