Video: Dab tsi yog synonymous thiab nonsynonymous mutation?
2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36
Cov DNA no kev hloov pauv hu ua synonymous kev hloov . Lwm tus tuaj yeem hloov cov noob uas tau qhia thiab cov phenotype ntawm tus neeg. Kev hloov pauv uas hloov cov amino acid, thiab feem ntau yog cov protein, hu ua kev hloov pauv tsis sib xws.
Hais txog qhov no, kev hloov pauv tsis yog lus txhais li cas?
A nonsynonymous hloov pauv yog ib nucleotide kev hloov pauv uas hloov cov amino acid ib ntus ntawm cov protein. Kev hloov pauv tsis muaj npe txawv ntawm qhov sib txawv hloov s, qho ua tsis hloov cov amino acid sequences thiab yog (qee zaum) ntsiag to kev hloov pauv s.
Tsis tas li ntawd, kev hloov pauv hloov pauv cuam tshuam li cas rau kev noj qab haus huv? Txawm hais tias feem ntau nws tau xav tias, hauv tib neeg, synonymous mutations yuav tsis muaj nyhuv ntawm kev qoj ib ce , cia nyob ib leeg ua rau muaj kab mob, txoj haujlwm no tau raug nug txog kaum xyoo dhau los. Tam sim no muaj ntau yam pov thawj tias qhov ntawd kev hloov pauv tau Piv txwv li, cuam tshuam splicing thiab cuam tshuam nrog miRNA khi.
Ib yam li ntawd, nws raug nug, qhov kev hloov pauv hloov pauv tshwm sim nyob qhov twg?
A synonymous kev hloov yog qhov hloov pauv hauv DNA ib ntus uas cov lej rau cov amino acids hauv cov protein ntau, tab sis ua tsis hloov cov amino acid encoded. Vim qhov redundancy ntawm cov noob caj noob ces (ntau codons code rau tib amino acid), cov kev hloov no feem ntau tshwm sim nyob rau hauv peb txoj hauj lwm ntawm ib codon.
Dab tsi yog qhov chaw sib koom ua ke?
Cov kev hloov pauv uas hloov cov txheej txheem coding (CDS), tab sis tsis hloov cov amino acid sequences yog hu ua lub ntsiab lus kev hloov pauv. Synonymous sites yog ces cov sau muaj peev xwm lub ntsiab lus mutations muaj nyob rau hauv ib tug gene. Cov codons sib txawv rau tib cov amino acid feem ntau siv ntawm qhov tsis sib xws ntawm cov genome.
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