Coomassie xiav siv rau hauv SDS PAGE yog dab tsi?
Coomassie xiav siv rau hauv SDS PAGE yog dab tsi?

Video: Coomassie xiav siv rau hauv SDS PAGE yog dab tsi?

Video: Coomassie xiav siv rau hauv SDS PAGE yog dab tsi?
Video: Qhia saib yus tus hlub lub xov tooj seb nws kov txog dab tsi thaum yus nyob deb 2024, Kaum ib hlis
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Yog · Tsis yog

Ntxiv mus, vim li cas Coomassie xiav siv hauv SDS PAGE?

Coomassie Blue stain yog siv rau stain cov protein bands hauv polyacrylamide gels. Cov dyes khi nruj dua rau cov protein ntau dua li cov gel matrix, txawm li cas los xij, yog li cov xim tom qab tuaj yeem raug tshem tawm ntawm tsuas yog cov khoom tsis muaj protein ntau ntawm cov gel siv cov kuab tshuaj zoo sib xws uas cov dye raug tshem tawm. Qhov no yog lub destain.

Ib yam li ntawd, cov amino acids dab tsi Coomassie xiav khi rau? Nyob rau hauv acidic tej yam kev mob, cov dyes khi rau cov proteins feem ntau los ntawm cov amino acids yooj yim (feem ntau. arginine , lysine thiab histidine ), thiab tus naj npawb ntawm coomassie dye ligands khi rau txhua tus protein molecule yog kwv yees li proportional rau tus naj npawb ntawm cov nqi zoo pom ntawm cov protein.

Ib sab saum toj no, lub luag haujlwm ntawm bromophenol xiav hauv SDS PAGE yog dab tsi?

Nws yog feem ntau siv raws li kev taug qab zas xim thaum lub sij hawm agarose los yog polyacrylamide gel electrophoresis. Bromophenol xiav muaj qhov tsis zoo me ntsis thiab yuav txav mus rau tib qho kev taw qhia zoo li DNA, tso cai rau tus neeg siv los saib xyuas qhov kev nce qib ntawm cov molecules txav mus los gel . Tus nqi ntawm kev tsiv teb tsaws txawv nrog gel muaj pes tsawg leeg.

Lub luag haujlwm ntawm SDS hauv SDS PAGE yog dab tsi?

Nws siv sodium dodecyl sulfate (SDS) molecules los pab txheeb xyuas thiab cais tawm protein ntau molecules. SDS-PAGE yog ib lub tshuab electrophoretic tsis tu ncua tsim los ntawm Ulrich K. Laemmli uas feem ntau siv los ua ib txoj hauv kev los cais cov proteins nrog molecular masses ntawm 5 thiab 250 KDa.

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