Dab tsi ua rau somatic hypermutation?
Dab tsi ua rau somatic hypermutation?

Video: Dab tsi ua rau somatic hypermutation?

Video: Dab tsi ua rau somatic hypermutation?
Video: Ua Dab Tsi Txhaum Koj - David Yang (New Song 2021) 2024, Kaum ib hlis
Anonim

Somatic hypermutation (los yog SHM) yog ib lub xovtooj ntawm tes uas lub cev tiv thaiv kab mob yoog rau cov khoom txawv teb chaws tshiab uas tawm tsam nws (xws li cov kab mob microbes), raws li pom thaum lub sij hawm hloov chav kawm. Somatic hypermutation Koom nrog cov txheej txheem kev hloov pauv uas cuam tshuam rau thaj chaw sib txawv ntawm cov noob ntawm immunoglobulin.

Tom qab ntawd, somatic hypermutation tshwm sim li cas?

Somatic hypermutation yog qhov tshwm sim uas muaj ntau zaus ntawm qhov kev hloov pauv tau tsim nyob rau hauv ib ntu 1-2-kb hauv thaj tsam sib txawv ntawm cov noob tshuaj immunoglobulin hauv kev teb rau qhov muaj cov tshuaj tiv thaiv.

Kuj Paub, puas yog somatic hypermutation tshwm sim hauv T hlwb? Somatic hypermutation ua tsis yog tshwm sim hauv T - cell receptor genes, yog li qhov sib txawv ntawm CDR1 thiab CDR2 cheeb tsam yog txwv rau cov germline V gene segments. Txhua qhov sib txawv hauv T - cell cov receptors yog generated thaum rearrangement thiab yog yog li ntawd tsom rau thaj tsam CDR3.

Tom qab ntawd, lub hom phiaj ntawm somatic hypermutation yog dab tsi?

Somatic hypermutation yog txheej txheem uas tso cai rau B hlwb hloov cov noob uas lawv siv los tsim cov tshuaj tiv thaiv. Qhov no ua rau cov B hlwb tsim cov tshuaj tiv thaiv zoo dua tuaj yeem khi rau cov kab mob, kab mob thiab lwm yam kab mob.

Qhov twg somatic recombination tshwm sim?

Somatic recombination tshwm sim ua ntej kev sib cuag antigen, thaum lub sij hawm B cell loj hlob nyob rau hauv cov pob txha pob txha.

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