Video: Dab tsi yog qhov tsis zoo p53?
2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36
Mutation ntawm p53 ua qog suppressor noob yog qhov kev hloov pauv caj ces feem ntau hauv tib neeg mob qog noj ntshav. Ntxiv nrog rau qhov poob ntawm kev ua haujlwm, mutant p53 ua tuaj yeem muaj ib tseem ceeb tsis zoo cuam tshuam rau hom tsiaj qus p53 ua thiab/lossis nce kev ua haujlwm ntawm nws tus kheej ntawm cov tsiaj qus-hom protein.
Kuj nug, dab tsi yog qhov cuam tshuam tsis zoo?
tseem ceeb tsis zoo . Ib qho kev hloov pauv uas nws cov khoom lag luam cuam tshuam tsis zoo rau cov khoom qub, hom tsiaj qus hauv tib lub cell. Qhov no feem ntau tshwm sim yog tias cov khoom tseem tuaj yeem cuam tshuam nrog tib lub ntsiab lus raws li cov khoom lag luam qus, tab sis thaiv qee yam ntawm nws txoj haujlwm.
Dab tsi yog qhov cuam tshuam ntawm kev hloov pauv tsis zoo? Dominant negative mutations (tseem hu ua antimorphic kev hloov pauv ) muaj cov khoom hloov pauv hloov pauv uas ua antagonistically rau hom tsiaj qus allele . Cov no kev hloov pauv feem ntau ua rau muaj kev hloov pauv molecular muaj nuj nqi (feem ntau tsis ua haujlwm) thiab yog tus cwj pwm los ntawm a tseem ceeb los yog semi- tseem ceeb phenotype.
Tom qab ntawd, lo lus nug yog, yog p53 dominant lossis recessive?
p53 ua kev hloov pauv tuaj yeem ua haujlwm li ib tseem ceeb negative, txhais tau hais tias ib tug mutated p53 ua protein tuaj yeem tiv thaiv kev ua haujlwm ntawm cov protein uas tsim los ntawm cov tsis hloov pauv.
Ib qho piv txwv ntawm kev hloov pauv tsis zoo yog dab tsi?
Cov kab mob no muaj xws li PKU, nqaij dystrophy, Huntingon's disease, Tay-Sachs kab mob, cystic fibrosis, thiab ntau lwm tus. Qhov tseeb, yog tias a kev hloov pauv cuam tshuam rau qee qhov kev ua haujlwm genome, xws li coding rau cov protein lossis RNA, lossis cov kev cai ntawm cov haujlwm ntawd, nws tuaj yeem tsis muaj txiaj ntsig, muaj txiaj ntsig zoo, lossis tsis zoo nyhuv.
Pom zoo:
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