Helicase kev ua si yog dab tsi?

2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36

Qhov no puas pab tau?

Yog · Tsis yog

Ntxiv mus, lub helicase ua li cas?

helicase . Helicases yog cov enzymes uas khi thiab tuaj yeem hloov kho nucleic acid lossis nucleic acid protein complexes. Muaj DNA thiab RNA helicases . DNA helicases Nws yog ib qho tseem ceeb thaum lub sij hawm DNA replication vim hais tias lawv cais ob-stranded DNA mus rau hauv ib tug strands cia txhua strand yuav luam.

Tsis tas li ntawd, lub substrate ntawm helicase yog dab tsi? Helicases yog cov enzymes uas siv lub zog ntawm ATP hydrolysis los catalyze DNA strand hloov chaw. Lub zog yog siv los rhuav tshem cov hydrogen bonds ntawm ob lub ntsiab lus ntawm nucleic acid substrate thiab hloov mus raws DNA strand uas lub enzyme yog khi.

Ib yam li ntawd, lub helicase tshwm sim ua dab tsi?

Muaj nuj nqi. Helicases yog Feem ntau siv los cais cov kab ntawm DNA ob lub helix los yog tus kheej-annealed RNA molecule siv lub zog los ntawm ATP hydrolysis, txheej txheem tshwm sim los ntawm kev tawg ntawm hydrogen bonds ntawm annealed nucleotide bases.

Leej twg nrhiav tau helicase?

Lub xub ntiag ntawm Fe-S pawg hauv DNA helicase enzymes yog thawj zaug nrhiav pom hauv XPD, tus tsim tswv cuab ntawm pab pawg kho DNA helicases (DDX11, RTEL-1, FANCJ) uas unwind duplex DNA nrog 5'-3' polarity thiab cuam tshuam rau tib neeg chromosomal instability teeb meem (Rudolf li al., 2006).