Video: Ib qho enhancer ua dab tsi?
2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36
Hauv cov noob caj noob ces, ib qho kev txhim kho yog qhov luv (50-1500 bp) thaj tsam ntawm DNA uas tuaj yeem khi los ntawm cov proteins (activators) txhawm rau txhawm rau ua kom qhov kev hloov pauv ntawm cov noob tshwj xeeb yuav tshwm sim. Cov no cov proteins feem ntau yog hu ua transcription yam. Enhancers yog cis-acting.
Ib yam li ntawd, tus txhim kho ua haujlwm li cas?
Txhim kho cheeb tsam yog kev sib txuas ua ke, los yog qhov chaw, rau cov ntsiab lus hloov pauv. Thaum DNA-bending protein khi rau ib qho ua kom zoo , cov duab ntawm DNA hloov. Txhim kho : Ib enhancer yog DNA ib ntus uas txhawb nqa kev hloov pauv. Txhua enhancer yog ua los ntawm luv DNA sequences hu ua distal tswj ntsiab.
Tsis tas li ntawd, dab tsi yog cov yam ntxwv ntawm kev txhim kho? Enhancers yog cov kab ke uas ua rau kom muaj kev hloov pauv ntawm cov neeg txhawb nqa. Lawv cov cim tseem ceeb tshaj plaws yog tias lawv ua haujlwm nyob rau hauv txoj haujlwm- thiab kev taw qhia-kev ywj pheej nyob hauv ob peb kb ntawm DNA uas transcription lawv modulate.
Ib yam li ib tug yuav nug, qhov txawv ntawm tus txhawb nqa thiab tus txhawb nqa yog dab tsi?
Ib ua kom zoo yog ib ntu ntawm DNA uas ua haujlwm los txhim kho kev hloov pauv. A txhawb nqa yog ib theem ntawm DNA uas pib cov txheej txheem ntawm kev sau ntawv. A txhawb nqa yuav tsum nyob ze rau cov noob uas tau muab sau tseg thaum ib ua kom zoo tsis tas yuav tsum nyob ze rau cov noob ntawm kev txaus siab.
Dab tsi yog ib qho putative enhancer?
Keeb kwm. Txhim kho yog cov tsis-coding DNA sequences, uas thaum lawv raug khi los ntawm cov proteins tshwj xeeb nce qib ntawm cov noob transcription. Txhim kho qhib cov cim qhia cov qauv hauv cov hlwb ntawm ntau hom lossis nyob rau hauv cov xwm txheej sib txawv.
Pom zoo:
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