Muaj pes tsawg post translational modifications muaj?

Video: Muaj pes tsawg post translational modifications muaj?

2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36

Ntau tshaj 200 ntau hom PTMs tam sim no paub (5, 6), xws li tshuaj me me kev hloov kho (piv txwv li, phosphorylation thiab acetylation) rau qhov sib ntxiv ntawm cov proteins kom tiav (piv txwv li, ubiquitylation, Daim duab 3).

Raws li, hom kev hloov pauv hloov pauv tom qab yog dab tsi?

Posttranslational kev hloov kho Cov proteins xws li phosphorylation, acetylation, AMPylation, ubiquitination, thiab ubiquitin-zoo li kev hloov kho.

Ib tug kuj yuav nug, qhov twg hauv lub cell puas hloov pauv hloov pauv tshwm sim? Tshaj tawm - kev hloov kho kev txhais lus ua tau tshwm sim ntawm cov amino acid sab chains lossis ntawm cov protein C- lossis N-termini. Lawv tuaj yeem txuas ntxiv cov tshuaj repertoire ntawm 20 tus qauv amino acids los ntawm kev hloov kho cov pab pawg ua haujlwm uas twb muaj lawm lossis qhia txog ib qho tshiab xws li phosphate.

Tsis tas li ntawd, peb hom kev hloov kho tom qab kev txhais lus yog dab tsi?

Cov no kev hloov kho suav nrog phosphorylation, glycosylation, ubiquitination, nitrosylation, methylation, acetylation, lipidation thiab proteolysis thiab cuam tshuam yuav luag txhua yam ntawm cov cell biology thiab pathogenesis.

Ib qho piv txwv ntawm kev hloov pauv hloov pauv ntawm cov protein yog dab tsi?

Tshaj tawm - kev hloov kho kev txhais lus (PTM) ntawm cov proteins ua lub luag haujlwm tseem ceeb hauv kev ua haujlwm ntawm tes. PTM yog qhov sib ntxiv ntawm qee pawg ua haujlwm rau lub cov proteins . Piv txwv yog cov zymogens, uas yog cov ntaub ntawv tsis muaj zog ntawm cov enzymes thiab tau qhib los ntawm kev tshem tawm ntawm qee feem ntawm cov enzymes. protein ntau.

Pom zoo:

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