Ip3 ua haujlwm li cas hauv txoj kev inositol phospholipid?
Ip3 ua haujlwm li cas hauv txoj kev inositol phospholipid?

Video: Ip3 ua haujlwm li cas hauv txoj kev inositol phospholipid?

Video: Ip3 ua haujlwm li cas hauv txoj kev inositol phospholipid?
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IP3 ua haujlwm li cas hauv txoj kev inositol phospholipid ? Nws khi rau thiab qhib Ca2+ channels uas yog embedded hauv ER membrane, tso Ca2+ rau hauv cytosol. Ua ke nrog CA2+, nws recruits PKC los ntawm cytosol mus rau plasma membrane thiab ua rau nws.

Yog li ntawd, inositol triphosphate ua dab tsi?

Thaum DAG nyob hauv daim nyias nyias, IP3 yog soluble thiab diffuses los ntawm lub cell, qhov twg nws khi rau nws receptor, uas yog ib tug calcium channel nyob rau hauv lub endoplasmic reticulum. Thaum IP3 khi nws cov receptors, calcium tso tawm rau hauv cytosol, yog li ua kom muaj ntau yam calcium tswj intracellular signals.

Ib yam li ntawd, ip3 receptors nyob qhov twg? Cov tus neeg txais kev pab muaj ib tug dav cov ntaub so ntswg faib tab sis tshwj xeeb tshaj yog muaj nyob rau hauv lub cerebellum. Feem ntau ntawm InsP3Rs pom muaj kev koom ua ke rau hauv endoplasmic reticulum.

Ib yam li ntawd, phospholipase C ua li cas?

Phospholipase C (PLC) yog ib chav kawm ntawm daim nyias nyias cov enzymes uas cleave phospholipids ua ntej pawg phosphate (saib daim duab). Nws yog feem ntau coj los ua ke nrog tib neeg cov ntaub ntawv ntawm cov enzyme no, uas ua lub luag haujlwm tseem ceeb hauv eukaryotic. cell physiology, tshwj xeeb teeb liab transduction txoj kev.

Puas yog inositol triphosphate dej soluble?

IP3 yog me me thiab dej soluble. Nws diffuses rau hauv cytosol qhov twg nws khi rau IP3-gated calcium tso cov channel hauv endoplasmic reticulum.

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