Sickle cell anemia yog ib qho piv txwv ntawm kev xaiv ntuj li cas?
Sickle cell anemia yog ib qho piv txwv ntawm kev xaiv ntuj li cas?

Video: Sickle cell anemia yog ib qho piv txwv ntawm kev xaiv ntuj li cas?

Video: Sickle cell anemia yog ib qho piv txwv ntawm kev xaiv ntuj li cas?
Video: Sickle Cell Anemia 2024, Kaum ib hlis
Anonim

Nov yog li cas natural xaiv tuaj yeem khaws cov teeb meem allele hauv cov noob caj noob ces: Allele (S) rau kab mob - cell anemia yog ib qho teeb meem autosomal recessive. Nws tshwm sim los ntawm kev hloov pauv hauv ib txwm allele (A) rau hemoglobin (cov protein ntawm cov ntshav liab hlwb ). Heterozygotes (AS) nrog rau kab mob - cell allele yog resistant rau malaria.

Ua raws li qhov no hauv kev txiav txim siab, pes tsawg cell anemia ua piv txwv ntawm kev hloov pauv li cas?

Ib lub noob hu ua HbS yog qhov chaw ntawm kev kho mob thiab evolutionary Dab neeg tshawb nrhiav uas tau pib hauv nruab nrab xyoo 1940 hauv Africa. Cov kws kho mob pom tias cov neeg mob uas muaj kab mob ntshav qab zib , ib hom kab mob ntshav loj heev, muaj feem yuav muaj sia nyob malaria, ib tus kab mob uas tua qee tus neeg 1.2 lab txhua xyoo.

Ib yam li ntawd, vim li cas ho tsis xaiv tej yam ntuj tso tshem tawm cov kab mob cell anemia? Ntuj xaiv tsis tuaj yeem tshem tawm tag nrho cov noob uas ua rau qhov no kab mob vim tias kev hloov pauv tshiab tshwm sim feem ntau - nyob rau hauv kab tias 1 ntawm 4000 gametes. Allele tej zaum yuav tshwm sim, thiab tsis yog deleterious, nyob rau hauv ib qho chaw nyob ze.

Ua ke, yog Sickle Cell Anemia Ib qho piv txwv ntawm kev cuam tshuam kev xaiv?

Kev xaiv cuam tshuam : ntuj xaiv tawm tsam "nruab nrab": extremists ciaj sia. Cov noob rau PKU tau rov qhia dua rau tib neeg cov noob caj noob ces los ntawm kev hloov pauv. Ntuj xaiv tshem tawm cov neeg tsawg tsawg uas yog homozygous recessive rau qhov no qhov zoo . Ntuj xaiv thiab human biology: Sickle cell anemia.

Kev hloov pauv dab tsi ua rau mob qog ntshav ntshav ntshav?

Kev hloov pauv hauv HBB gene ua rau mob mob cell . Hemoglobin muaj plaub lub subunits protein, feem ntau, ob subunits hu ua alpha-globin thiab ob subunits hu ua beta-globin. HBB noob muab cov lus qhia rau kev ua beta-globin.

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