Qhov twg silencers khi?

Video: Qhov twg silencers khi?

2024 Tus sau: Miles Stephen | [email protected]. Kawg hloov kho: 2023-12-15 23:36

A Silencer yog ib ntus tshwj xeeb uas ua rau muaj kev cuam tshuam tsis zoo rau kev hloov pauv ntawm nws cov noob tshwj xeeb. Nyob ntawd yog ntau txoj haujlwm uas a Silencer keeb ua tau nyob rau hauv DNA. Txoj hauj lwm feem ntau yog pom nyob rau sab sauv ntawm lub hom phiaj gene qhov twg nws ua tau pab repress lub transcription ntawm cov noob.

Xav txog qhov no, qhov twg txhim kho khi?

Txhim kho tuaj yeem nyob rau sab saud ntawm cov noob, nyob rau hauv cheeb tsam coding ntawm cov noob, nqes dej ntawm cov noob, lossis ntau txhiab nucleotides deb. Thaum DNA-bending protein khi mus rau ua kom zoo , cov duab ntawm DNA hloov, uas tso cai rau kev sib cuam tshuam ntawm cov cov activators thiab transcription yam tshwm sim.

Ib yam li ntawd, puas yog cov tshuaj tiv thaiv kab mob thiab cov silencers hauv prokaryotes? Hauv genetics, ib ua kom zoo yog ib qho luv luv (50-1500 bp) thaj tsam ntawm DNA uas tuaj yeem khi los ntawm cov proteins (activators) txhawm rau ua kom qhov kev hloov pauv ntawm ib qho gene yuav tshwm sim. Muaj ntau pua txhiab tus tshuaj kho kom zoo nyob rau hauv tib neeg genome. Lawv muaj nyob rau hauv ob qho tib si prokaryotes thiab eukaryotes.

Tsis tas li ntawd, cov proteins dab tsi khi rau kev txhim kho?

Txhim kho sequences yog cov kev cai DNA sequences uas, thaum khi los ntawm tej cov proteins hu ua transcription factor, txhim khu cov transcription ntawm ib tug txuam gene.

Puas yog cov kev hloov pauv tau khi rau cov khoom txhawb nqa?

Transcription yam yog proteins uas khi cov chaw tshwj xeeb lossis cov ntsiab lus hauv cheeb tsam tswj hwm ntawm DNA, hu ua cov neeg txhawb nqa lossis tshuaj kho kom zoo , qhov twg lawv tswj lub kev sau ntawv los yog kev nthuav qhia ntawm cov hom phiaj. Cov DNA- kev khi domain muaj cov amino acids uas paub txog cov DNA tshwj xeeb ntawm cov txheej txheem tswj.

Pom zoo:

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Enhancers ua haujlwm raws li 'tig rau' hloov hauv gene qhia thiab yuav qhib thaj tsam txhawb nqa ntawm ib qho gene thaum silencers ua raws li 'tig' hloov. Txawm hais tias ob txoj cai tswjfwm no ua haujlwm tawm tsam ib leeg, ob hom kab ke cuam tshuam rau thaj tsam txhawb nqa hauv txoj hauv kev zoo sib xws